Award Data

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymerSELPsilk elastinlike proteinKto embolize cerebral aneurysmsThe SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for del ...

Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

A new dual pump hydraulic supply designed to enable energetically autonomous exoskeleton robots will be developed, tested and demonstrated. This new hydraulic supply will be integrated with a high performance hydraulically actuated full body exoskeleton robot and used to test and demonstrate the overall performances of such systems. New control policies that include: (i) an assist mode, where the ...

The proposed strategy in this STTR proposal for bioconversion of food waste to butanol uses the well-described Clostridium acetobutylicum organism to convert the carbohydrate to the fuel molecule butanol. Based on our teams many years of work with butanol formation and genetic studies of the organism and the advancement of recently developed genetic methods, the team will develop a set of genetic ...

Recently, fiber/yarn-based energy-storage systems have attracted enormous attention due to their remarkable promises in smart textiles and high-tech sportswear etc., mainly as more pliable energy-storage units being truly wearable. Storagenergy Technologies Inc. proposes to develop graphite fibers (GFs), which are fabricated by a scalable and cost effective wet spinning approach, and later chemica ...

Robotic autonomous systems (RAS) are currently being used for many different applications using a wide variety of vehicle platforms. The environments in which RAS are being used are becoming increasingly complex. Vehicle path planning and control is challenging in environments with many obstacles and uneven terrain. This proposed research will develop and compare multiple techniques to improve veh ...

Biomimetic Slope Adaptive Foot-Ankle Prosthesis This project will develop an innovative mechanical/hydraulic foot-ankle system that will help lower extremity prosthesis wearers to walk or run in a wider range of environments with close to normal walking biomechanics. The proposed system will have a unique combination of features, all mechanically implemented without electronics or external powe ...