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Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

In order to enable reliable predictions based on full scale vehicle simulations relevant to high-speed ISR missions, detailed interactions among various nonequilibrium physical phenomena and their coupling to turbulent flow structures, characterized by a broad range of length/time scales, need to be accurately modeled. Although detailed predictions can be obtained using detailed state-to-state kin ...

The state-of-the-art in infrared scene projection uses micro-machined resistor arrays. These arrays have limited frame-rate, dynamic range, and can be cost prohibitive as the array size increases. Alternative technologies are required. The most promising is infrared light emitting diodes (IR LED) based on InAs/GaSb type-II superlattices (T2SL) or W-Quantum Wells, with the ability to tune the bandg ...

The Air Force has identified a need for a display agnostic common streaming model for 3D data. Third Dimension Technologies (TDT) and Oak Ridge National Laboratory (ORNL) have formed a consortium to define a 3D streaming model based on open standards for Display Agnostic 3D Streaming (DA3DS). Two factors are driving this need. The first is the dramatic increase in the collection, storage and trans ...

Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures.This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation.A unique microstructure for the tubular anode will be produced using a novel freeze-casting techniq ...

"Atmospheric Glow Technologies (AGT) proposes to initiate studies to elucidate the mechanism of inactivation of microorganisms using atmospheric plasma. In this Phase I work effort, AGT will identify and quantify the active species generated by the APD-210(Atmospheric Plasma Decon-210). The APD-210 has been independently shown to inactivate a number of different microorganisms including anthrax ...

"The future battlefield will feature highly advanced targeting and firepower and will therefore require significant advancements in real-time information feed back for individual soldiers. Advanced communications and sensors systems can inform the soldierand his commander of, for example, the locations and identities of hazards and details of his physical condition. To advance this goal, radio-f ...

The transcription factor CAAT enhancer binding protein beta (C/EBPbeta) is a key factor orchestrating the inflammatory response. Specifically, expression of the genes encoding the pro-inflammatory cytokines IL-6 and on IL-8 are regulated by C/EBPbeta. C/EBPbeta can be either an activator or an inhibitor of inflammation depending on the dominant isoforms produced. Our data indicate that airway epit ...