Award Data

DESCRIPTION provided by applicant The human transcriptome is significantly more complex than its cognate genome due to the hundreds of thousands of possible isoforms allele specific expression issues variable RNA editing changes and differential expression patterns spanning cell types developmental stages and physiological stresses Next generation sequencing NGS platforms are fundame ...

DESCRIPTION provided by applicant Staphylococcus is the most common cause of infections worldwide The pathogen persists asymptomatically on human skin from which it may spread to ocular tissues and cause corneal infection When this happens corneal bacterial keratitis can occur and if not treated effectively it may lead to blindness Multi Drug Resistant MDR variants of S aureus Sa are ...

DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

DESCRIPTION provided by applicant Neurodegenerative diseases that affect motor neurons such as PD ALS and HD represent an enormous unmet medical need that is growing with the aging population Existing treatments have little or no effect on the course of disease and patients have to cope with the loss of brain and body function for the rest of their lives Defects in the transport of organell ...

DESCRIPTION provided by applicant The goal of iFIT Prosthetics LLC r and its founder was to create and commercialize a modular immediate fit fully adjustable transtibial prosthesis system suitable for mass production using high strength polymer materials that are injection molded at a fraction of the cost of conventionally made prostheses This goal was achieved and now the aims of this P ...

DESCRIPTION provided by applicant Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwide Importantly in humans the majority of morbidity and mortality following flu infection is seen in older individuals andgt year old Yet clear understanding of how aging impacts on innate immune responses and how to improve vaccine design ...