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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Rational design of small interfering RNA for genome-wide target knockdown

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Real-time myoglobin saturation measurement to assess benefit of RBC transfusion

    SBC: OPTICYTE INC            Topic: NHLBI

    DESCRIPTION provided by applicant Critically ill patients commonly arrive at an intensive care unit with anemia While blood transfusions are the standard of care with the intention to increase or maintain oxygen delivery to tissues questions have been raised about the benefit of blood transfusions particularly in non bleeding patients with moderate anemia A noninvasive measure of intracellu ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A Low Cost, Quantitative, Chemical Specific Device for Illicit Drug Detection

    SBC: MKS Technology            Topic: NIDA

    DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Continuous measurement of cell growth as an optimal tool in drug toxicity testing (Supplement)

    SBC: EnTox Sciences LLC            Topic: NCATS

    DESCRIPTION provided by applicant During the process of screening for drugs with therapeutic potential often times several candidates emerge as prime candidates with similar efficacy and the choice for a lead compound is difficult to make However peopleandapos s lives and billions of dollars may rest on the choice of which compound to bring to clinical investigation and trials Since any lev ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Ultra-Sensitive Diagnosis of AIDS-Related Tuberculosis

    SBC: AttoDx, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant This grant will develop a novel strategy to enhance the analytical sensitivity of polymerase chain reaction PCR based detection of bacteria in samples We will commercialize the strategy in the form of a pre PCR andquot turbo chargerandquot to be marketed in conjunction with PCR based molecular diagnostic systems The current STTR project will apply this str ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Clonotyping Technology for Prediction of Antibiotic Resistance

    SBC: ID GENOMICS SPC            Topic: NIAID

    DESCRIPTION provided by applicant The primary goal of this Phase I STTR proposal is to develop a prototype of a rapid molecular diagnostics test to improve prediction of the antibiotic resistance of uropathogenic Escherichia coli by determining their clonal identity clonotype The clonotype determination will be done by detection of the presence absence of a limited number d of single ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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