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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An Open-Source Platform for Inter-Network Analytics of High-Consequence Events

    SBC: ANOMALEE INC.            Topic: DTRA14B003

    Objectives and Intellectual Merit: The infrastructure of modern civilization is a set of complex systems1 that dynamically interact across multiple layers of abstraction. Researchers from many disciplines2 are designing analytical tools for predicting the global and local behaviors of these complicated, multi-layer networks. Easily usable, available (open source) and inter-operated tools are neede ...

    STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
  2. Measuring Bladder Permeability with MRI using a Novel Contrast Agent Formulation

    SBC: Lipella Pharmaceuticals Inc.            Topic: 400

    DESCRIPTION provided by applicant This project entails the development of a novel dual component MRI contrast agent formulation for the detecting permeability in the luminal surface of the urinary bladder The purpose of having such a test is ultimately to allow clinicians in certain circumstances to differentially diagnose a chronic non infectious inflammation of the urinary bladder from a ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A Low Cost, Quantitative, Chemical Specific Device for Illicit Drug Detection

    SBC: MKS Technology            Topic: NIDA

    DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Novel mass spectrometry methods for profiling modified RNA nucleotides in the nervous system

    SBC: Ribonova Inc.            Topic: NIDA

    DESCRIPTION provided by applicant Pseudouridine is the most abundant post transcriptionally modified nucleoside found in ribonucleic acid RNA Pseudouridine is an enzymatically generated isomer of the canonical base uridine with additional hydrogen bonding capabilities and appears to lead to local structural and biochemical effects within RNAs Pseudouridine has been detected in several type ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. mTOR Substrate Phosphorylation: A New Bioassay for Therapeutics

    SBC: COGNIZANCE BIOMARKERS, LLC            Topic: 107

    DESCRIPTION provided by applicant There are a growing number of human diseases that have been linked to abnormally enhanced activation of the mammalian target of rapamycin mTOR signaling cascade a central pathway governing eukaryotic protein synthesis These include neurodevelopmental disorders associated with epilepsy autism and intellectual disability as well as cancer obesity and dia ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Serious STEM Games To Educate Middle School Students

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: OD

    DESCRIPTION provided by applicant Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Neurotrophic Agents for Treating Parkinson's Disaese

    SBC: SENEB BIOSCIENCES INC            Topic: 102

    DESCRIPTION provided by applicant Parkinsonandapos s disease PD is a neurodegenerative disorder characterized by motor function and eventually cognitive decline GM depletion is validated as a therapeutic target for Parkinsonandapos s disease PD in clinical studies in which GM replacement stabilized motor function loss and may be disease modifying However GM has poor pharmacologic prop ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A Low-Cost Portable Multiplex Serum Molecular Test for HBV and HCV Detection

    SBC: LENIMA FIELD DIAGNOSTICS LLC            Topic: R

    DESCRIPTION provided by applicant Hepatitis B HB and hepatitis C HC are two of the most widespread infections worldwide caused by the blood borne HB virus HBV and HC virus HCV respectively About million and million people suffer from chronic HB CHB and chronic HC CHC respectively while about and people die each year due to the consequence of HB and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Novel sigma-2 receptor modulators for the treatment of cognitive dysfunction

    SBC: COGNITION THERAPEUTICS, INC.            Topic: NIA

    DESCRIPTION provided by applicant Cognition Therapeutics Inc andapos s mission is to develop effective therapeutics for Alzheimerandapos s disease AD Recent scientific discoveries have identified oligomers of the brain protein A as toxic culprits in disease progression Cognition in partnership with Temple University has identified a novel series of sigma receptor binding modulators t ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. DEVELOPMENT OF SMALL MOLECULE THERAPEUTICS AGAINST RNA VIRUSES

    SBC: FOX CHASE CHEMICAL DIVERSITY CENTER INC.            Topic: R

    DESCRIPTION provided by applicant The ultimate goal of this project is to produce a broad spectrum drug for the treatment of viral infections caused by filoviruses Ebola and Marburg arenaviruses Lassa fever and rhabdoviruses rabies We and others have determined that efficient budding of these emerging human pathogens is dependent on the subversion of host proteins such as Nedd and t ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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