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ABSTRACT: The goal of head-worn display systems is to increase situation awareness and reduce operator workload. The urgent need is for higher image resolution and lower system latency, while meeting constraints on head-borne weight and power. Current processor solutions cannot meet increased requirements. The challenge is that power consumption is proportional to the amount of data being handled, ...

Recent advances in mammalian artificial chromosome design and engineering offer an alternative to existing methodologies for cellular bioengineering and address unmet needs to bioengineer more complex functionalities into human cells for subsequent commercialization. In this ST13B-001 application we propose to demonstrate utility of a novel chromosome-based gene delivery vehicle that is amenable t ...

The emergence of metal-organic frameworks has presented an untapped potential for solving US Army individual and collective protection issues. The majority of work on MOF synthesis has been done at lab scale, yielding milligram or gram quantities. To test practical devices, scale up of MOF synthesis processes to kilogram quantities is necessary. However, most large commercial suppliers are uninte ...

The Area-I team proposes to leverage its expertise and extensive design, analysis, and simulation tools to evaluate the design space of towed magnetic anomaly detection (MAD) systems with the goal of understanding the design trends and requirements in developing a new, lightweight rotorcraft-towed anti-submarine warfare (ASW) system that is optimized to take advantage of smaller state-of-the-art M ...

ABSTRACT: R-DEX Systems proposes to develop the Terabit Optical COMMunications (TOCOMM) System to radically improve airborne Free-Space Optical (FSO) communications. TOCOMM will combine proven spatial, spectral, and polarization multiplexing, advanced coding and channel equalization, advanced optics, advanced laser communications and state-of-the-art pointing, acquisition and tracking (PAT) tech ...

DESCRIPTION provided by applicant Glycans have several distinct properties that make their development as disease biomarkers appealing Firstly their location on cell surfaces makes them the first point of contact for cellular interactions and thus they are crucial in the control of normal metabolic processes and conversely they function as pathogen adhesion receptors Secondly specific gl ...

DESCRIPTION provided by applicant The ability to accurately quantitate the glycan chains attached to glycoproteins has wide ranging implications Numerous studies over the past years have demonstrated that abnormal glycosylation occurs in virtually all types of human cancers and demonstrate the potential of using glycan markers in either a diagnostic or a prognostic manner The glycosylatio ...

DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...