Award Data

At the completion of the research and development effort a Li foil multi-wire proportional counter (MWPC) neutron detector with more than 625 cm^2 of active area will be included in a portable radiation detection system. The system is expected to have an intrinsic thermal neutron detection efficiency of 55% or greater and gamma-ray rejection ratio (GRR) of 1.0x10^-8 or better. A gamma-ray spectrom ...

DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access ...

DESCRIPTION provided by applicant Advanced approaches for genetic or epigenetic modification of embryonic stem ES cells including TALEN ZFN or CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAs synthetic mRNAs or recombinant transcription factors have revolutionized our ability to modify the cells from which novel mouse lines are produced In contra ...

DESCRIPTION (provided by applicant): A New Modular Tool Set for Live Imaging and Manipulating the Nervous System Project summary. The nervous system contains the most complex and heterogeneous set of cell types in the body. Modern approaches in imaging, an d genetically encoded reporters based on the Green Fluorescent Protein (GFP), have made it possible to explore some of the dynamic processes in ...

DESCRIPTION (provided by applicant): A novel enhanced dynamic range camera (EDRaC) is proposed for greatly improved fluorescence detection in proteomics. In the longer term the EDRaC can improve the performance of a wide range of biomedical applications us ing fluorescent microwell plate reading and/or microscopy. The initial emphasis will be to develop, demonstrate, and apply the technology to mu ...

DESCRIPTION (provided by applicant): Process automation has become an essential element of all modern crystallography facilities. Robotic equipment allows crystals of biological macromolecules to be produced in greater numbers and rapidly mounted thus resu lting in more efficient utilization of valuable X-ray resources. The need to maximize the productivity of these resources becomes more acute wi ...

DESCRIPTION (provided by applicant): Protein posttranslational modifications (PTMs) control much of biology. Glycosylation is one of the most common PTMs and more powerful tools are needed to study the occurrence and relative levels of glycosylation. In th is proposal we describe the development of new multicolor fluorescent labeling reagents designed for powerful, differential glycomics analysis. ...

DESCRIPTION (provided by applicant): The broad long-term goals of this project are to develop more powerful proteomics detection technology with greatly improved sensitivity, that will reveal the global patterns of biologically stimulated changes (differen tial detection) in protein levels, posttranslational modifications and enzyme activities simultaneously (using 6-12 channel multicolor fluoresc ...