Award Data

At the completion of the research and development effort a Li foil multi-wire proportional counter (MWPC) neutron detector with more than 625 cm^2 of active area will be included in a portable radiation detection system. The system is expected to have an intrinsic thermal neutron detection efficiency of 55% or greater and gamma-ray rejection ratio (GRR) of 1.0x10^-8 or better. A gamma-ray spectrom ...

DESCRIPTION provided by applicant With million young athletes participating in contact sports and between to million concussions endured by young athletes yearly in the US subjective concussion identification increases risk of death time lost from school cognitive decline chronic traumatic encephalopathy CTE depression suicide dementia Alzheimerandapos s and Parkinsona ...

DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant The American Diabetes Association has declared type diabetes T D a public health crisis T D begins as a state of compensated insulin resistance frank disease develops when of insulin producing pancreatic islet cells of affected individuals undergo cell death Endoplasmic reticulum ER stress has emerged as a central underlying mechanism that drive ...

DESCRIPTION provided by applicant Approximately Americans suffer from vision loss due to Retinitis Pigmentosa RP Despite significant progress in elucidating the molecular genetics of RP over the past three decades no disease modifying therapies have been approved There is compelling evidence implicating endoplasmic reticulum ER stress in the pathogenesis of various forms of RP e ...

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in the United States, accounting for approximately 1 million deaths per year. The objective of the Phase I pre-clinical studies outlined in this fasttrack STTR proposal is to validate the proposed methods of isolation, characterization, and administration of preferred progenitor cell prepar ...

DESCRIPTION (provided by applicant): The emergence of technologies enabling isolation of adult stem cells has allowed evaluation of cell therapeutics for central nervous system disorders with a path for clinical development. Much promise has been shown using stem cells in acute disease models such as stroke or hypoxic injury to the brain, and as well to chronic degenerative diseases such as Park ...

DESCRIPTION (provided by applicant): Case Western Reserve University researchers and BioInVision, Inc. will develop a cryo-imaging system for 3D imaging of mice. It will serve applications in stem cell regenerative medicine, metastatic cancer, and pathogen/immune system response, among others. By alternately sectioning and imaging, the system will enable one to acquire 3D high-resolution color and ...

DESCRIPTION (provided by applicant): Evidence-based treatment for pediatric bipolar disorder (BPD) is sorely lacking. While pharmacology remains the first-line treatment, psychosocial interventions are considered essential for comprehensive care. Currently there are no published large-scale, randomized clinical trials of psychosocial intervention for pediatric BPD; however, one is nearing completi ...

DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport mechanisms) excludes most blood-bor ...