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DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant Osteoarthritis OA diagnosed in over of the US population is the primary cause of musculoskeletal lower extremity disability Although there is no cure exercise remains the core treatment to manage OA regardless of age comorbidity pain severity or disability Yet many people with this condition do not engage in regular fitness and thus may resort t ...

DESCRIPTION provided by applicant The long term goal of this project is to develop and test a nutritional product that will improve physical function in individuals with heart failure H in the geriatric population Our approach to nutritional therapy NT focuses on increasing skeletal muscle strength improving vascular reactivity and optimizing regulation of energy substrate metabolism All ...

DESCRIPTION provided by applicant The overall goal of this project is to test a meal replacement beverage that will ultimately preserve muscle loss during calorie restriction weight loss CRWL in obese older individuals We previously developed a meal replacement rich with a proprietary blend of essential amino acids TMR that was more than three times as effective as whey protein in stimulat ...

DESCRIPTION provided by applicant This multi phase SBIR project targets a significant problem within the mission of the National Institute of General Medical Sciences rapid size based separation of small Da molecules in bio manufacturing The aim here is to simplify and radically improve this currently multi stage and a resource intensive process Manufacturing of active pharmaceut ...

DESCRIPTION provided by applicant The objective of this Phase I proposal is to demonstrate the feasibility of an innovative Cloud Information Management Bundle system CLIMBandquot that will increase efficiency and improve capabilities in animal model data management Current data management systems for animal model research have limitations For example paper based recording systems used by ...

DESCRIPTION provided by applicant We propose to evaluate the functionality MRI and bio compatibility of probes for microscopic magnetic stimulation mMS a new brain stimulation technology Moreover it has been demonstrated that the orientation of the applied MS fields relative to the excitable tissue provides unique activation of neuronal elements not seen with traditional electrical st ...

DESCRIPTION provided by applicant There are an estimated million Americans with chronic kidney disease CKD Early diagnosis and treatment are the only cost effective means to reverse this growing problem NIH recognizes the challenge to diagnose CKD early during its initiation and development phases in order to prevent further renal damage reduce cardiovascular risk and minimize the econ ...