Award Data

DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant Celiac disease CD is the most common food sensitive enteropathy known affecting approximately of the population and its incidence appears to be on the rise In addition non celiac gluten sensitivity GS has recently been revealed to be a distinct condition that affects a growing number of individuals Both of these conditions are triggered by gluten a ...

DESCRIPTION provided by applicant Polypharmacology represents a new and attractive approach to treat malignances as lasting and robust efficacy could be obtained through the inhibition of multiple survival pathways with one therapeutic agent In line with this method we have designed a RET rearranged during transfection VEGFR vascular endothelial growth factor receptor small molecule ...

DESCRIPTION provided by applicant Pathological activating mutations in the FLT kinase represent the most common genetic alteration in patients with acute myeloid leukemia AML occurring in approximately one third of cases Recently we performed translational studies that identified drug resistant kinase domain mutations in FLT ITD at the time of relapse in AML patients treated with the FLT ...

DESCRIPTION provided by applicant Inflammatory disease states are leading causes of death and disability and a major cost to healthcare in the United States There is an epidemic of death and hospitalizations due to adverse effects from NSAIDs TAI LCx Turmeric Anti Inflammatory Lipophilic Component X is a novel anti inflammatory discovered in previously unrecognized pharmacologically activ ...

DESCRIPTION provided by applicant Osteoarthritis OA diagnosed in over of the US population is the primary cause of musculoskeletal lower extremity disability Although there is no cure exercise remains the core treatment to manage OA regardless of age comorbidity pain severity or disability Yet many people with this condition do not engage in regular fitness and thus may resort t ...

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death in the United States and other developed countries. The treatment of cardiovascular disease often involves surgically bypassing occluded segments of blood vessels with human saphenous vein grafts. Approximately 1,000,000 aortocoronary and peripheral revascularizations are performed using human saphenous vein ...

DESCRIPTION (provided by investigator): The overall aim of this project is to discover a reproducible means to translate the scientific advances of the -biomedical healthcare delivery culture to the culture of minority populations. The goal of Phase I is to develop a case-based, interactive Internet continuing education (CE) program to improve health care providers' ability to understand and comm ...

A remarkable and unexpected interaction effect between high frequency ultrasound energy and bioelectrically excitable tissue will be employed to the development of a line of advanced microstimulators for medical neurogenic applications An excised nerve preparation as well as hippocampal tissue slices of the rat brain will be used as physiologic models for further study of the ultrasound interactio ...

Because of the repetitive trauma to the upper extremities that results from wheelchair propulsion, the prevalence of pain and injury in manual wheelchair users is alarmingly high. By understanding the mechanisms in the development of arm pain, we can begin to prevent the pain. The SMART(Wheel) is a tool that enables direct measurement of the forces and torques applied by wheelchair users to the pu ...