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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Rational design of small interfering RNA for genome-wide target knockdown

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A Low Cost, Quantitative, Chemical Specific Device for Illicit Drug Detection

    SBC: MKS Technology            Topic: NIDA

    DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Therapeutic Agents for Diabetic Ulcers

    SBC: AUXAGEN, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Diabetes mellitus afflicts 20.8 million people, or 7% of the population, in the United States. Fifteen percent, or 2.4 million people, will develop diabetic foot ulcers in their life time. Diabetic foot ulceration and i nfections are a major cause of hospitalization of diabetic patients. The direct and indirect costs of ulcer management and treatment exceed 10 ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. Development of High Temperature Cryopreservation Medium for Storage and Shipping

    SBC: IMPACT BIOLABS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): One of the most expensive aspects of a cryopreservation program is related to ongoing, long-term storage and shipping of samples at very low temperatures (typically between - 196oC, the temperature of liquid nitrogen (L N2), and approximately -120oC, in the high- end temperature range of LN2 vapor). Current approaches to cryopreserving most cells and tissues, i ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Development of an Open Source Research Management System

    SBC: MRH CONSULTING SERVICES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The pharmaceutical industry has access to well-designed clinical trial management software (CTMS) for their studies. Specialized CTMS packages are essential for drug trials but are not optimal for other kinds of clinica l research, such as observational, epidemiological, and mechanistic studies, nonpharmacological intervention trials, health behavior research, ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  8. A Universal Micromanipulation Robot for Crystallography

    SBC: Square One Systems Design, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Process automation has become an essential element of all modern crystallography facilities. Robotic equipment allows crystals of biological macromolecules to be produced in greater numbers and rapidly mounted thus resu lting in more efficient utilization of valuable X-ray resources. The need to maximize the productivity of these resources becomes more acute wi ...

    STTR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
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