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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Non-Dispersive Reaction and Separation Processes for Pharmaceutical Synthesis

    SBC: CHEMTOR, L.P.            Topic: 300

    DESCRIPTION provided by applicant A number of pharmaceutical reactions and wash processes involve interaction between immiscible phases within reactors or extraction equipment Multi phase synthesis processes have been traditionally been carried out through dispersion of one of the phases into the other in the form of droplets Such arrangement increases the surface area of interaction thereby ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A novel racial disparity marker for risk prediction in triple negative breast cancer patients

    SBC: NOVAZOI THERANOSTICS            Topic: NIMHD

    DESCRIPTION provided by applicant Breast cancers in African American AA women are characterized by earlier onset higher aggressiveness more extensive metastases and increased mortality rates compared to those in European American EA women This breast cancer related health disparity is partly due to the fact that AA women are more likely than EA women to develop a particularly aggressive ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Small Molecules To Inhibit PCSK9-LDLR

    SBC: Small Molecules PPI Mimics, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant This proposal is to prepare small molecules that will inhibit the protein protein interaction between a protein called PCSK and the LDLR receptor This is an extremely well validated target for reduction of andquot badandquot cholesterol LDL and therefore controlling coronary artery disease Orally available small molecules are the preferred therapeutic mo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A Low Cost, Quantitative, Chemical Specific Device for Illicit Drug Detection

    SBC: MKS Technology            Topic: NIDA

    DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Using game mechanics to improve outcomes among stem cell transplant survivors

    SBC: Radiant Creative Group, LLC            Topic: NCI

    DESCRIPTION provided by applicant Adolescent and young adult AYA hematopoietic stem cell transplantation HSCT patients face a variety of well documented physical and emotional challenges In addition to undergoing a life threatening procedure that involves an intense treatment regimen and lengthy hospital stay these patients face a protracted month recovery period marked by numerous phy ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Triple Re-uptake Inhibitor, SKL 10406, as a New Treatment for Alcohol Dependence

    SBC: Medication Discovery Texas, Inc            Topic: NIAAA

    DESCRIPTION provided by applicant Three medications are approved by the FDA as treatments for alcohol dependence disulfiram acamprosate and naltrexone but these are seldom prescribed due to poor efficacy or side effects Another topiramate is effective for reducing alcohol use but it causes a range of side effects that limit its tolerability Another clas of potentially effective treatment ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Lactoferrin Modulation of Granuloma Pathology

    SBC: PHARMAREVIEW CORPORATION            Topic: NIAID

    DESCRIPTION provided by applicant Host immunity plays a major role in development of Tuberculosis disease Tuberculosis infected individuals respond by formation of granulomas which contain bacilli However organisms within granulomas are protected from the full scope of immune mediated defenses We hypothesize that modulation of destructive immune mediated pathology while preserving essent ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Green Algal Strains for Biological Control of West Nile Virus Mosquitoes

    SBC: Pond Life Technologies Limited Liability Company            Topic: NIAID

    DESCRIPTION provided by applicant West Nile virus WNV has become endemic to the US with yearly infection peaks coinciding with the activity of its mosquito vector was the worst year for WNV since with deaths and estimates of non neuroinvasive cases There is no specific treatment or vaccine so mosquito control is the only approach available Fortunately controll ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Blood-based diagnostics for Alzheimer's Disease

    SBC: Amprion, Inc.            Topic: NIA

    DESCRIPTION provided by applicant This proposal is for a phase I II fast track project for the STTR program with the main goal to develop a blood test for Alzheimerandapos s disease AD diagnosis AD is the most common dementia in the elderly population and one of the leading causes of death in the developed world One of the main problems in AD is the lack of an early sensitive and objective ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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