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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. CCN3-derrived peptides to treat liver injury

    SBC: BLR Bio            Topic: 200

    Project Summary Chronic liver disease is becoming a major public health issue with estimates of up to 40% prevalence of non- alcoholic fatty liver disease (NAFLD) and 12% with non-alcoholic steatohepatitis (NASH) in the U.S. Liver disease and cirrhosis was the 12th leading cause of mortality in the U.S. in 2014. Obesity and metabolic syndrome are important causes of fatty liver disease or steatosi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Enhanced Software Tools for Detecting Anatomical Differences in Image Data Sets

    SBC: Ligo Analytics            Topic: 105

    Project Summary Morphometric analysis is a primary algorithmic tool to discover disease and drug related effects on brain anatomy. Neurological degeneration and disease manifest in subtle and varied changes in brain anatomy that can be non-local in nature and effect amounts of white and gray matter as well as relative positioning and shapes of local brain anatomy. State-of-the-art morphometry meth ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growth

    SBC: ReveraGen BioPharma, Inc.            Topic: NICHD

    There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Dressing Assistant: Home Technology to Sustain Independent Dressing in Dementia

    SBC: Inventors' Workshops, Inc.            Topic: NIA

    AbstractPersons living with dementiaPWDoften require assistance with routine activities and daily tasksWorkloads placed on caregivers often results in high levels of physical and emotional stressand depressionand higher overall morbidity and mortality ratesFocus group of caregivers for individuals with mild to moderate dementiaidentified dressing the PWD as the most pressing and stressful daily co ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Imaging Biomarkers of Severe Respiratory Infections in Premature Infants

    SBC: Kitware, Inc.            Topic: NHLBI

    ABSTRACTPrematurity is the largest single cause of death in children under five in the world and lower respiratory tract infectionsLRTIare the top cause of hospitalization and mortality in premature infantsClinical tools to predict and prevent severe LRTI in premature pediatric patients are critically needed to allow early interventions to decrease the high morbidity and mortality in this patient ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Quantitative Magnetic Resonance Imaging Phantoms

    SBC: Calimetrix, LLC            Topic: NIBIB

    PROJECT SUMMARYThe overall goal of this Phase I proposal is to designdevelop and test the feasibility of advanced quantitative magnetic resonance imagingMRIphantoms that mimic the simultaneous presence of fatiron and fibrosisFatiron and fibrosis are three principal histological coexisting features of many important disease statesPhantoms are highly controlled test objects that accurately reflect t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Evaluation of a Novel Infection PET Diagnostic

    SBC: CHRONUS PHARMACEUTICALS, INC.            Topic: NIBIB

    Project Summary Abstract Bacterial infections such as those of prosthetic jointsbonesosteomyelitisand heart valvesinfective endocarditisare difficult to difficult to diagnose and treatand are a major cause of mortalitymorbidity and health care costsThe long term goal of our program is thus to develop positron emission tomographyPETradiotracers that can be used for non invasive PET imaging to detec ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviors

    SBC: Weinberg Medical Physics, Inc.            Topic: NIDA

    Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. staRt: Enhancing speech treatment with smartphone-delivered biofeedback

    SBC: Girlfriends Labs LLC            Topic: NIDCD

    Project Summary Abstract Children with speech sound disorder show diminished accuracy and intelligibility in spoken communication and may thus be perceived as less capable or intelligent than peerseven when they are of average or above average intellectual abilityWhile most speech errors resolve by the late school age yearsup toof individuals will continue to exhibit residual speech errorsRSEthrou ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. MtLDL detection to diagnose childhood tuberculosis

    SBC: CHRONUS PHARMACEUTICALS, INC.            Topic: NIAID

    Project SummaryChildhood TB is estimated to contributeof the disease burden in high burden settingswith approximately a million cases per year inworldwideExisting gold standard diagnostic culture tools fail to confirm TB in most childrenwho typically have low bacterial counts and cannot produce sputumMore sensitive and child friendly diagnostic tools are urgently needed to diagnose TB in childrenC ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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