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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Endoscopically-guided optical coherence tomography for early cancer screening

    SBC: PHYSICAL SCIENCES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a need for an improved technology for early cancer detection and rapid screening. Recent advances in nanotechnology and high resolution imaging have led to the development of new investigative t ools capable of probing biological tissues at the cellular level. These tools can be used to localize abnormal neoplastic cells and expedite th ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  3. Enhanced Contrast Imaging for Screening of Early Pancreatic Cancer

    SBC: PHYSICAL SCIENCES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a real need for an improved technology for early detection and rapid screening of ductal pancreatic cancer. Very recent advances in nanotechnology and high resolution optical coherence tomography (OCT) imaging have led to the development of new investigative tools capable of probing biological tissues at the cellular level. These tools ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  4. The Crystal Optimizer: Kinetic Control of Protein Crystallization

    SBC: RAINDANCE TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Protein crystallization remains a bottleneck in the goal to determine the protein's structure. A microfluidic device denoted the Crystal Optimizer (XOpt) has been developed to optimize the kinetic pathway for the nuclea tion and growth of protein crystals once the lead conditions have been identified by other screening methods. The device drives each of hundred ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

    SBC: RESONANCE RESEARCH INC            Topic: N/A

    DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly fro m the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fi ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. A low-cost point-of-care diagnostic test for simultaneous HIV-1 and STI

    SBC: Infoscitex Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): An important approach for HIV/AIDS prevention is to diagnose co-infections that significantly increase the transmission of HIV. In this proposal, we propose to develop a rapid point-of-care (POC) test that simultaneous ly diagnoses HIV-1 and two sexually transmitted infections (STI's). Syphilis and genital herpes are STI's that enhance HIV transmission; if dia ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Development of small near-infrared laser system capable of improving immune respo

    SBC: SEMINEX CORPORATION            Topic: NIAID

    DESCRIPTION (provided by applicant): The broad and long-term objective of this project is to amplify the effectiveness of vaccines without the use of chemical or biological adjuvants. We will address this objective by demonstrating the feasibility for small laser- based devices to enhance responses to intradermal vaccination. A number of investigators have shown that a promising new way to make va ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Therapeutic Utility of renalase and renalase peptides in cisplatin-mediated renal

    SBC: BESSOR PHARMA, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Cisplatin is a cornerstone therapy for a number of cancers including testicular, bladder, ovarian and lung. It is also used to treat cancers in children. In all cases there is a high incidence of acute kidney injury (AKI) that can also lead to later stage kidney damage. This risk limits its use. We have found in pilot studies that renalase, or peptide fragment ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. DNP Polarization Agents for Real-Time Metabolic Imaging and Clinical Diagnosis

    SBC: DYNUPOL, INC.            Topic: NCI

    Project Summary / Abstract Although standard MRI techniques provide valuable structural insight, a related technique known as magnetic resonance spectroscopy (MRS) adds powerful real-time metabolic information about the tissues under study. MRS provides early detection of disease, monitoring treatment efficacy, and, in the case of cancer, a dramatic reduction in unnecessary biopsies. However, bro ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Developing Inhibitors of the STARS/SRF Pathway for Treatment of Type 2 Diabetes

    SBC: Jenesis Biosciences LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) has reached epidemic proportions in the United States, affecting an estimated 8.3% of the population. Unfortunately, the majority of individuals with diabetes continue to have suboptimal control ofglucose, therefore new and improved approaches to prevention and treatment are sorely needed. Dr. Mary Elizabeth Patti's laboratory at the ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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