Award Data

DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I Project tests the feasibility of applying Agile Sciences' technology to decreasing or eliminating biofouling on filtration membranes used for drinking water purification. The main obstacle in efficiently applying membrane filtration to provide safe dri ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase I project propose a new method of producing enantiomerically pure ketones through the use of ACC chiral auxiliaries. The synthesis of single enantiomer drugs is an extremely important aspect of drug development. Current methods to both produce and/ ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will develop a multifunctional graphene-platinum composite for hydrogen fuel cells. High performance fuel cells currently have inefficient catalyst utilization due to limited contact between Pt nanoparticles and the solid proton conductor. This ...

DESCRIPTION (provided by applicant): The objective of this STTR proposal is to develop a 2-D diffusion point-of-care assay (POC) for B-type natriuretic peptide (BNP). The primary goal of the proposed work is to create a test format that will allow patientswith chronic heart failure to quantitatively self-monitor serum levels of BNP. Determination of baseline level of BNP and changes in this level ...

DESCRIPTION (provided by applicant): The goal of this STTR Phase I proposal is to develop a searchable Internet database of prevention lessons called Prevention Buffet. The database will allow middle school teachers to customize prevention efforts in their classrooms to the needs of their students, while providing them with guidance in selecting and implementing prevention lessons. Lessons will be ...

DESCRIPTION (provided by applicant): Atrial fibrillation remains the most commonly occurring cardiac arrhythmia. It is associated with a lower quality of life and a higher rate of morbidity and mortality. Cryotherapy and radiofrequency catheter ablations for the purpose of eliminating atrial fibrillation have become a mainstream treatment option. They produce lesions that block the spread of elect ...

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...

This Small Business Technology Transfer Research (STTR) Phase I project proposes to develop and commercialize a fully implantable, integrated, ultra-flexible device for high-bandwidth bidirectional interface with the central nervous system aimed at brain-computer interfacing (BCI) and neurobiology research applications. The device will incorporate the implantable component of the multichannel wire ...

This Small Business Technology Transfer (STTR) Phase I project proposes to develop novel biotech plant lines with improved rates of photosynthesis in a canopy setting. The improved rates of photosynthesis will enable increases in intrinsic crop yield. Photosynthesis has evolved on an individual, rather than a population basis, resulting in reduced photosynthetic efficiency on a population basis in ...