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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Electronics and computational hardware for ultra-high channel count electrophysio

    SBC: Leaflabs, LLC            Topic: 101

    DESCRIPTION provided by applicant The advent of in vivo multielectrode recording has indicated the importance of recording from large populations of neurons As a result there is much interest in creating new kinds of in vivo multielectrode arrays including the polytrode new kinds of microfabricated electrode arrays and new kinds of ultradense D electrode array And yet innovation on the ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Fluorescence Lifetime Dynamics to Understand Brain Neural Activities and Behavior

    SBC: ChiSquare Bioimaging, LLC            Topic: 500

    DESCRIPTION provided by applicant The overall objective of the proposed project is to create a compact robust and easy to use device that is capable of sensitive and quantitative detection of fluorescence lifetime indicators of physiological and biochemical dynamics deep in the brain of a freely moving mouse In contrast to fluorescence intensity based methods fluorescence lifetime can delin ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Optopatch: high-throughput all-optical electrophysiology for neural recording

    SBC: Q-State Biosciences, Inc.            Topic: 102

    DESCRIPTION provided by applicant Optopatch high throughput all optical electrophysiology for neural recording The convergence of stem cell genomic and advanced imaging technologies provides unprecedented ability to study human neural physiology in health and disease Traditionally intractable diseases schizophrenia autism Alzheimerandapos s ALS and Parkinsonandapos s are being modeled ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Transitioning Electronic Support for Public Health (ESP) from Lab to Marketplace

    SBC: Commonwealth Informatics, Inc.            Topic: 400

    DESCRIPTION provided by applicant Accurate and complete disease surveillance is critical to enable public health authorities to detect and respond to disease outbreaks epidemics and even bioterrorism events While legally required of healthcare practitioners and practices most notifiable disease reporting is still done manually or through limited automated laboratory test result reporting ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. New heterocyclic inhibitors of filoviruses

    SBC: MICROBIOTIX, INC.            Topic: H

    DESCRIPTION provided by applicant Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral i ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Nitric Oxide Microfluidic Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant This Small Business Innovation Research SBIR Phase I project aims to develop a microfluidic based nitric oxide NO sensor as an early sepsis risk assessment device Sepsis causes significant strain on the U S healthcare system consuming over $ billion annually due to extended hospital stays and significant morbidity and mortality Rapid diagnosis and in ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. XRpro Radioactive Cesium Decorporation Agents

    SBC: Icagen, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Caldera aims to develop an inexpensive stable selective decorporation decorp agent for cesium Cs Cs is easily obtainable by terrorists and treatments for exposures are Project Bioshield priorities for use in radiation nuclear emergencies high priority for DHHS NIH NIAID DAIT and a critical need for the Strategic National Stockpile S ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Cell therapy for Repairing Warm Ischemically Damaged Kidneys

    SBC: BREONICS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The goal of this project is address a large unmet medical need by providing more kidneys for transplant For the andgt patients with end stage renal disease in the U S the pool of cadaveric kidneys has remained stagnant over the past decade As a result the dialysis population is expected to reach andgt million patients in the next decade at an aggr ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. New small molecule inhibitors of arenaviruses

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Lassa fever virus LASV and Machupo virus MACV are hemorrhagic fever arenaviruses which are classified as Category A Agents Currently there are no licensed LASV or MACV vaccines and LASV MACV therapy is limited to use of the nucleoside analog ribavirin which is only partially effective and associated with significant side effects The impact of arenavirus ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Selective agents against C. difficile infection

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The overall goal of this project is to develop a selective antibiotic against Clostridium difficile the major agent responsible for antibiotic induced diarrhea and colitis The pathogen can be carried in healthy individuals and is kept at bay by gut symbionts Antibiotic treatment suppresses the normal flora but spores of C difficile survive germinate and ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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