Award Data

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

Employment is essential for helping individuals with intellectual disabilities achieve independence, financial security, and self-sufficiency to be active members in the community as well as foster a higher quality of life more generally. However, only 25% of individuals with intellectual disabilities are employed two years after high school. Utilizing 3C’s proprietary dynamic e-learning platfor ...

Perfluoroalkyl substances (PFASs) have received considerable attention due to their toxicity, ubiquitous presence and recalcitrance. Manufacture and disposal of PFAS-containing products has resulted in PFAS contamination of numerous water supplies. Recent reports indicate the Air Force alone is expecting to spend > $2.25 billion for cleanup for PFAS-contaminated sites. Thus, there is a huge market ...

This green approach to manufacturing plastic with decorative chrome will eliminate health and environmental hazards from the chrome electroplating process. The US and global market for decorative chrome on plastic is 12 million m2/year and 84 million m2/year respectively, with 80% in automobile trim, 10% in appliances and 10% in sanitary fixtures. Without a viable commercial alternative, US provid ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

Abstract Atrial fibrillationAFprevalence is estimated toof the general population in the United StatesA shockingtoaccording to studiesof patients with AF are unaware of their diagnosissilent AFMost AF patients will suffer from congestive heart failure or and develop thromboembolic events leading to a dramatic reduction of patientsquality of lifeand a significant consumption of health care resource ...

DESCRIPTION (provided by applicant): This Phase I SBIR application is submitted in response to the call by DHHS for new tests for qualitative measurement of HCV RNA for diagnosis of chronic HCV infection in patients. The need is for HCV RNA assays that areas reliable but less expensive and resource-demanding than current molecular assays. The new test proposed for research and development consists ...

ABSTRACT Adolescents in underserved, urban communities are disproportionately involved in the juvenile justice system. Youth involvement in the court system is a serious public health concern. In recent years, juvenile justice professionals have begun to supplement traditional efforts aimed at discipline and punishment with an asset- based perspective referred to as positive youth justice (PYJ). ...

Project Summary Abstract Most of the deaths from drug overdoses are driven by synthetic opioidsDentistry highly contributes to the opiate addiction epidemicFollowing dental surgeryof oral surgeons prescribe opiatesand most opiates are prescribed after wisdom teeth extractionthird molarto reduce pain caused by dry socketsApproximatelymillion surgical tooth extractions are performed onmillion patien ...

The goal of this project is to develop a microand nanofluidic DNA sizing platform with a sensitivityspeedand dynamic range that is unmatched by current sizing technologiesWe find that fluorescence burst analysis of individual DNA molecules transported through sub micrometer scale channels provides accurate and precise sizing of fragments betweenbp ands of MbpIn this singlemolecule sizing platformu ...