Award Data

DESCRIPTION provided by applicant The leading cause of mortality in patients with cystic fibrosis CF is pulmonary failure from lung infections and the predominant organism isolated from these infections is the bacterium Pseudomonas aeruginosa Lung infections of CF patients persist over the lifetime of the patients and are impossible to eradicate due to the ability of bacteria to form biofi ...

DESCRIPTION provided by applicant In there were new cases of head and neck cancers HNC in the United States Early detection of new and locally recurrent cancers is clinically important to reduce not only cancer related mortality but also treatment associated morbidity as it impacts multiple organ functions including respiration olfaction hearing eating swallowing and speak ...

DESCRIPTION (provided by applicant): Pretest probability assessment (PTP) plays a pivotal role in the evaluation of pulmonary embolism (PE) in the emergency department (ED) and accurate PTP assessment can modify defensive test-ordering behavior by physicians. However, current methods of PTP assessment produce broad categories of risk that tend to over fit individual patients and seldom obviate tes ...

DESCRIPTION (provided by applicant): The purpose of this Phase II STTR is to complete the development of a web-based training system, the All Stars Online Community. This system is designed to improve teachers' delivery of All Stars, an adolescent substance use prevention program. The goal of training is to help teachers advance in their teaching skills and understanding of underlying preventi ...

This Small Business Technology Transfer Research (STTR) Phase II project will extend the basic science of linear interference delay effect filters, enabling ultra-wideband tunable RF filters for all types of RF receivers and instrumentation. It will also extend the engineering science of implementing such filters as integrated circuits. And, its distortion filtering aspect will enable enable signa ...

DESCRIPTION provided by applicant This Small Business Innovation Research SBIR Phase I project aims to develop a microfluidic based nitric oxide NO sensor as an early sepsis risk assessment device Sepsis causes significant strain on the U S healthcare system consuming over $ billion annually due to extended hospital stays and significant morbidity and mortality Rapid diagnosis and in ...

DESCRIPTION (provided by applicant): The Genomics Revolution and the resultant explosion of knowledge in genomics are shaping our futures. Therefore, it is crucial that knowledge of genomics is broadly disseminated, so that future scientists, educators, policy makers, community leaders, and heads of households can harness the beneficial power of genomic science. Given the indiscriminate impact of ...

During covert operations, the U.S. Army may be required to breach a concrete structure using a controlled explosion. When choosing the most effective charge size and placement, it is vital to perform a rapid field assessment of the material and structural properties of the target structure. However, high strength concrete materials (such as Ultra-High Performance Concrete), including steel fiber r ...

DESCRIPTION (provided by applicant): Septicemia is a medical syndrome characterized by an overwhelming systemic response to infection that can rapidly lead to shock, organ failure and death. In the U.S. septicemia is the 10th leading cause of death overall with over 750,000 cases and 215,000 deaths each year and accounts for $17 billion in annual health care expenditures. Following its release fr ...

DESCRIPTION (provided by applicant): The ultimate goal of this project is treatment of beta-thalassemia, a genetic blood disease, with antisense oligonucleotides. The project is based on the technology developed by the PI in which antisense oligonucleotides are used to restore correct functioning of a defective gene rather than, as commonly practiced, to inhibit the expression of an undesirable ge ...