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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Novel Lipotherapy to Reduce Infarct Size Following Myocardial Infarction

    SBC: ENDOPROTECH, INC.            Topic: NHLBI

    According to the CDC inischemic heart disease is the leading cause of death worldwideand in the US approximatelypatients died of ischemic heart diseaseIt is well established in clinical practice that recanalization of the infarct related arteryIRAusing percutaneous coronary interventionPCIenhances myocardial salvage and outcomes in patients with ST segment elevation myocardial infarctionSTEMIWhen ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Bitter Human Taste Bud Epithelial Cell Platforms for Bitter Taste Antagonist Discovery

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDCD

    Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Clinical Validation of the Multiple Biopsy Device, a Novel Endoscopic Biopsy Technology

    SBC: Endoscopy Assist Devices LLC            Topic: 102

    Project Abstract The objective of this proposal is to complete clinical validation of the Multiple Biopsy DeviceMBDan endoscopic device that will revolutionize endoscopic practice by improving the efficiency of endoscopic biopsyeliminating the loss of critical specimensand improving the safety of endoscopic biopsy for both practitioners and patientsOvermillion endoscopic procedures will require en ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Commercialization of a Rapid Blood Test for Traumatic Brain Injury

    SBC: Fawkes Biotechnology, LLC            Topic: 100

    Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Percutaneous Pulmonary Artery Drainage Device to Unload LV During VA ECMO Support for Severe Cardiogenic Shock

    SBC: W-Z Biotech LLC            Topic: NHLBI

    Cardiogenic shockCSis a serious clinical condition of reduced cardiac outputCOwith end organ hypoperfusionIn severe CSend organ hypoperfusion leads to multi organ failureand elevated left ventricleLVpreload increases LV wall stressexacerbating myocardial injuryVenoarterial extracorporeal membrane oxygenationVA ECMOhas been increasingly used to support severe CS patients due to its high efficiencyc ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a sutureless LVAD outflow graft anastomotic quick-connect system

    SBC: Myocardial Assist Systems & Technology LLC            Topic: NHLBI

    Heart failureHFis the leading cause of death in the United Statesaffecting nearly six million people at a cost over $billionClinically approved mechanical circulatory supportMCStherapysuch as left ventricular assist devicesLVADscontinue to improve as a viable treatment option for patients with advanced heart failure as evidenced by overimplants over the past five yearsHoweverMCS device therapy can ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a TransApical to Aorta Double Lumen Cannula for a Neonate LVAD

    SBC: W-Z Biotech LLC            Topic: NHLBI

    Left ventricular assist deviceLVADsupport allows the neonate with congenital heart disease or cardiomyopathy to grow to a larger body weight that is more feasible for complex surgical correction or heart transplantThe Berlin Heart ExCORis FDA approved for pediatric LVAD applicationAlthough this device is outside the bodythe outflow graft may still create coronary artery heart compressionOur ultima ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. DIAGNOSTIC TEST FOR METASTATIC KIDNEY CANCER

    SBC: LaGrange Scientific, LLC            Topic: 102

    ABSTRACTThe goal of this Phase I SBIR is to address the absence of measureable and targeted metabolite biomarkers in clear cell renal cell carcinomaccRCCtissues that can predict disease metastasisAn estimatedAmericans were diagnosed with kidney cancer inand approximatelydied as a result of ccRCCprimarily due to metastasis of the cancerUltimatelywe seek to identify those patients with more aggressi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluating Synthetic Biology Produced Triterpene Oils in Adjuvant Formulations

    SBC: Enepret Incorporated            Topic: NIAID

    ABSTRACT Vaccine adjuvants help stimulate the body to generate an immune response when co injected with an antigenthe compound for which immunity is desiredAlthough the human body is capable of producing antibodies to most injected antigensadjuvants can help boost the body s ability to mount a successful and acquired immune response to the presented targetAdjuvants have been shown to enhance immun ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Exploiting activation-induced cell death as a means of inducing tolerance to kidney allografts

    SBC: FasCure Therapeutics LLC            Topic: NIAID

    PROJECT SUMMARY Kidney transplantation is the preferred treatment for patients with end stage renal diseaseHoweverstandard immunosuppression to control rejection is the major limitationAlthough standard immunosuppression has gradually been improved for better efficacy and safetyit still carries a great risk for adverse effects ranging from malignancies and infections to cardiovascular complication ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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