Award Data

Cost-effective and minimally invasive monitoring of metastatic breast cancer (MBC) patients for disease progression or response to therapy is an unmet need in the clinical management of the disease. Imaging technologies are currently the gold standard of such monitoring. However, there is controversy regarding the type and frequency of imaging required. Imaging is expensive, time consuming, slow t ...

An advanced hit detection technology is needed for MDA that can report impacts at hyper-velocities and at multiple hit locations. We present a technology with a high level of performance that leverages decades of hit technology experience and utilizes existing technologies developed under previous efforts. Our technology offers a low latency non-interpolated direct indicator of multiple hit locati ...

To effectively characterize the Ballistic Missile Defense System (BMDS) using modeling and simulation (M&S), techniques from the fields of simulation optimization, analysis, and uncertainty quantification can be used, but these techniques require the execution hundreds or thousands of simulation runs. OptTek, a pioneer in commercial simulation optimization, initially designed search algorithms for ...

ABSTRACT The goal of this proposal is to repurpose technology developed for Next-Gen Proteomics to develop a highly-scalable digital serotyping technology for infectious disease analysis, with particular application to influenza and Covid-19. The approach is broadly applicable and should greatly improve upon cost, sensitivity, usability, and throughput of population-level serotyping and greatly im ...

Innew cases of breast cancerBCandrelated deaths are expected in the USof these are patients with aggressive triple negative BCTNBCor anti estrogen aromatase inhibitor resistantAE AIBC that do not have targeted therapy and rely on radiotherapy and aggressive chemotherapyA new approach that benefits these patients and provides increased life expectancy needs to be developedWe have identified GPa gly ...

ABSTRACT Tuberculosis ranks in the top ten worldwide cause of death and now ranks ahead of HIV, making it the number one infectious disease killer. Perhaps, most alarming is the global prevalence of multidrug-resistant TB (MDR- TB) and extensively drug-resistant TB (XDR-TB): more than 5% of new TB cases are MDR-TB and 10% of these have XDR-TB. And, the number of enrolled XDR-TB cases has grown fro ...

Abstract Chronic liver injury due to alcohol, metabolic dysfunction, viral hepatitis, or autoimmune disease results in liver inflammation and fibrosis. Liver fibrosis will progress to cirrhosis which is estimated to affect 1–2% of the world’s population. The major clinical consequences of cirrhosis are liver failure and hepatocellular carcinoma (HCC), both of which increase the risk of death. ...

To enhance Operational Test (OT) fidelity, increase automation, and shorten the testing process, the Missile Defense Agency (MDA) seeks innovative research efforts to develop scenario generation technologies. STILMAN proposes to conduct novel research to develop a highly automated and ‘composable’ scenario generation toolset. Currently, in the distributed system of systems Operational Test ...

PROJECT SUMMARY Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with cardiovascular and cardiothoracic diseases. An interventional catheter with forward-viewing ultrasound imaging capability will be developed to enable image-guided access to blood vessels and internal organs. Phase 1 and 2 experiments demonstrate feasibility of building a high res ...

This SBIR project will research mechanisms to detect when Health Care WorkersHCWsin hospitals steal ordivertlegal drugs either to abuse themselves or to illegally sell to othersWe focus on HCWs in hospitals because of the alarming rates of substance abuse and diversion in hospitalswith multiple studies finding roughlyof our nation s nursesanesthesiologistsand pharmacists are currently diverting dr ...