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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Using Connected Play To Engage Learners In Computational Thinking Practices Through Collaborative Problem Solving

    SBC: Makefully, LLC            Topic: 91990020R0006

    This project will develop a prototype that extends Makefully, a collaborative digital and physical multi-player puzzle-solving board game for math and computer science, with a focus on integrating music. The Phase I prototype will include additional physical and digital play modules and an adaptive component that provides feedback to students as they progress through the game to inform their learn ...

    SBIR Phase I 2020 Department of EducationInstitute of Education Sciences
  2. Toward the Development of a Protein: Non-protein Macromolecular Adjuvants

    SBC: Hafion LLC            Topic: NIAID

    An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tractOvercoming this problem will require the use of novel vaccine formulations andin particularthe use of novel immune enhancing agentsadjuvantsthat promote immune responses that are effective at mucosal sit ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Enzyme Replacement Therapy for Complement C2-Deficiency

    SBC: Nectagen, Inc.            Topic: NIAID

    The goal of this Phase I SBIR project is to develop a scalable method of Cpurification for use in Creplacement therapy based on a novel immunoaffinity chromatography resinDeficiency of complement CC Dis reported to be the most common hereditary defect among complement components with a prevalence ofPatients with homozygous complete deficiency suffer from recurring pyrogenic infections with encapsu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Object Oriented Data Analysis for Untargeted Metabolomics

    SBC: WILLIAM D SHANNON CONSULTING LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT In this Phase I SBIR applicationwe propose to develop and optimize functional Object Oriented Data AnalysisfOODAmethods and create a cloud based SaaS platform to analyze untargeted metabolomics dataUntargeted metabolomics quantifies the amount of known and unknown metabolites in samples with the purpose of finding known and unknown metabolites that correlate with subgroups ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Developing a Nutraceutical Product against Ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARYDespite recent advances in cancer therapiesplatinum based drugs are still widely used for the treatment of solid tumorsA primary example is cisplatinwhich is frequently used to treat lungbladdertesticularand cervical cancersHoweverlimitations of this therapy include the development of drug resistance in cancer cells as well as severe side effectssuch as nephrotoxicity and neurotoxic ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Diagnostic Test for Detecting Recent Seizures in Epilepsy Patients

    SBC: Sceptor Industries, Inc.            Topic: 106

    Project SummaryAbstractEpilepsy affects approximatelyof the world populationtotaling andgtmillion patientsWhile anti epileptic drugAEDtreatment is successful in many patientsof patients continue to experience seizures causing physicians to adjust change medications or other treatment parametersCurrent diagnostic tools are incapable of differentiating between patients experiencing a recent seizure ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Biologically Targeted Vaccine for Chikungunya

    SBC: PRECISION VIROLOGICS INC            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virusCHIKVis a mosquito transmitted alphavirus that causes explosive epidemics of a severe febrile illness characterized by debilitating polyarthralgia in humansCHIKV caused an estimatedmillion new cases in India alone inand has the potential to spread globally because of the distribution and abundance of its mosquito vectorsAedes aegypti and Aedes albopictusDu ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Magnetomotive Embolization for Hepatocellular Carcinoma

    SBC: UNandUP, LLC            Topic: 102

    Cancer is thend leading cause of death in the United StatesUSand accounts forof everydeathsMore thanAmericans will die of cancer inwith annual US cancer care expenditures reaching $B byand more thanM cancer related deaths occur annuallyWhile chemotherapy is effectiveseveral cancer subtypesincluding liver cancerare associated with a very lowyear survival rate of less thanIn additiononly a small pro ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Exo-Seq for the single molecule of DNA molecules

    SBC: Digital Nanogenetics LLC            Topic: 172

    ABSTRACT The long term goal of this project is the commercial development of a low cost Single Molecule SequencingSMStechnologycalled Exo Seqwhich employs a sequencing by subtraction strategy for high fidelity disassembly of low amounts of unamplified DNAsIn spite of the SMS approachExo Seq possesses superior single pass base call accuracyandgtusing a multiparameter identification strategy that ta ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Humanization, Production, and PK/PD Characterization of anti-TIP1 antibody against Non-Small Cell Lung Cancer

    SBC: Medical Guidance Systems LLC            Topic: 102

    The proposed developmental activity will result in a humanized monoclonal antibodyTiptuhumabwhich acts as a radiomodulator immunotherapeuticThis antibody targets the cancer neoantigenTax Interacting ProteinTIPand is cytotoxic to non small cell lung cancer cellsNSCLCFor patients with NSCLCtheyear overall survival rate iswith a median survival time ofmonthsThe challenge in treatment outcomes is part ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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