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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. To develop a customizable sample sparing

    SBC: Grace Bio-Labs, Inc.            Topic: NIAID

    Proposes to commercially develop a customizable sample sparingeasy to usecost effectiveand highly multiplexed protein microarray platform that will simultaneously measure multipleup toimmunoglobulin isotypes subtypes in the same sample across an entire landscape of multiple antigensThe platform is designed to define different effector functions for antibodies reactive with specifically mapped epit ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR Phase 1 Diagnostics to enable malaria and neglected tropical diseases

    SBC: Hemex Health, Inc.            Topic: NIAID

    While significant progress has been made in reducing malaria prevalence and deathsmalaria elimination remains a difficult goalSelection pressures have driven malaria transmitting mosquitos to new behaviorsrendering vector control methods less effectiveMass drug administration without diagnosis can increase the risk of developing drug resistanceAdditionallyPfalciparum and Pvivax species of malaria ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Practical Mass Spectrometry Upgrade for Identifying Fragile Protein Modifications by ECD

    SBC: E-Msion, Inc.            Topic: 400

    The speed resolution and high mass accuracy of modern mass spectrometers have revolutionized proteomics particularly for determining fragile post translational modifications that control most cellular processes Accurate identification and quantitation of phosphorylation sites remain a major challenge in proteomics The key weakness with mass spectrometry for phospho proteomics lies in the metho ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Training the brain with a robotic device for balance recovery in near frail older adults

    SBC: AMES TECHNOLOGY, INC.            Topic: NICHD

    DESCRIPTION provided by applicant The long term goal of this project is to reduce falls in older adults by improving their ability to recover equilibrium during a slip or trip The proposed strategy is to use AMES an FDA cleared non invasive intervention that has been shown to enhance motor performance in able bodied adults and to reduce sensorimotor impairment in both the upper and lower lim ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Dynamic Mining and Contextualization of the Scientific Literature This project creates interactive science articles and collects data metrics accelerating scientific discovery and reproducibility

    SBC: InSilico, Inc            Topic: 172

    The proposed Dynamic Mining and Contextualization of the Scientific Literature DMCSL provides an open lane of communication between authors science journals readers and databases The outcome of this communication portal will be a database containing mineable metadata for researchers reagent supply and biotech companies Data will be available to companies through individualized subscription ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Expanding the Click City Tobacco Prevention Program to Include E cigarettes and Other Novel Tobacco Products

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: NIDA

    The overarching goal of the proposed research is to demonstrate the feasibility of modifying an existing effective computer based tobacco prevention program Click City Tobacco funded by NIH R CA to prevent the initiation of e cigarette use e g e cigarettes and other vaping devices among youth Click City Tobacco is a school based program for th graders with a booster in th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Cytomegalovirus based therapeutic vaccine for chronic hepatitis B

    SBC: TOMEGAVAX, INC.            Topic: R

    Abstract Although an efficient prophylactic vaccine is available for hepatitis B virus HBV chronic hepatitis B CHB affects up to million people worldwide and despite advances remains mostly incurable In adults acute HBV infection is cleared in of cases by CD T cell mediated mechanisms but chronic lifelong infection ensues in the remaining individuals which can lead to liver ci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Mindfulness Mobile App to Reduce Adolescent Substance Use

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: NIDA

    ABSTRACT Adolescents in the juvenile justice system demonstrate very high rates of tobacco alcohol and other drug use ATOD with rates that are estimated to be three times higher than non justice involved youth Substance abusing youth especially those who are involved in the juvenile justice system are at higher risk than nonusers for mental health problems including depression conduct ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Nanoparticle based targeted codelivery of siRNA and taxane to treat drug resistant HER breast cancer

    SBC: PDX PHARMACEUTICALS, LLC            Topic: 102

    This SBIR Fast Track application focuses on the development of a nanoconstruct for co delivery of siRNA and chemotherapy drugs to drug resistant human epidermal growth factor receptor type positive HER breast cancer HER breast cancer is a subtype that presents HER overexpression and accounts for of invasive breast cancers HER breast cancer has poor prognosis despite the rigorou ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Deep Learning Models for Biomarker Identification and Classification

    SBC: AMPLION INC.            Topic: 400

    Nearly half of all biomedical publications ever written have been published in the last years the era since the completion of the human genome project The rate of increase is exponential shows no signs of slowing down and can be seen in all of the information sources relevant to precision medicine development This constitutes a nearly insurmountable burden for the drug development and diag ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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