Award Data

There is unmet need for rapid, cost effective in vitro methods to identify chemicals that pose a hazard to the human brain. A number of in vitro assays utilizing primary cells have been tested in an effort to devise effective models to prioritize chemicals for further in depth toxicity studies. However, isolation of primary human neural tissue is cost and labor intensive, and cannot be produced in ...

DESCRIPTION provided by applicant Most clinical assays begin with blood collection in a laboratory setting The Gates foundation and many others have recognized and attempted to deal with the fact that in much of the world clinical testing is done in a primitive setting The luxury of having a phlebotomist to draw blood with a laboratory to prepare serum or plasma for analysis is not universal ...

DESCRIPTION provided by applicant In an effort to reduce the use of animals for toxicity testing companies have developed in vitro skin models or equivalents to replace the Draize skin irritation test This development has been further pushed by the European Union regulation that has prohibited the use of animals for collecting toxicological data on cosmetic ingredients that began Supply ...

DESCRIPTION provided by applicant Mass spectrometry based proteomics is an emerging technology that has seen possible applications everywhere The technique can potentially use one drop of our blood to reveal onset and progress of diseases Current Randamp D using plasma serum proteome sample sets however is severely limited by the high complexity and dynamic range of protein concentrations ...

DESCRIPTION provided by applicant A policy statement by the World Health Organization notes that the male latex condom is the single most efficient available technology to reduce the transmission of HIV and other sexually transmitted infections Unfortunately despite decades of condom promotion efforts condoms usage rates remain disappointingly low Between one third and one half of men ...

DESCRIPTION provided by applicant Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients Circulating tumor cells CTCs in the bloodstream are key players in the establishment of metastatic tumors Recent studies demonstrated that the number of CTCs present in patient blood directly correlate with cancer progression recurrence and survival rate ...

DESCRIPTION provided by applicant Anxiety disorders are the most common psychiatric disorders among youth with lifetime prevalence ranging between of the general population Among anxiety disorders social anxiety disorder SAD affects of all youth resulting in significant short and long term impairment including increased likelihood of substance abuse limited academic achievemen ...

DESCRIPTION provided by applicant Pediatric Food Allergy FA is recognized as a serious public health concern that affects approximately percent of children with symptoms affecting multiple organ systems including skin the respiratory tract and the GI tract Food induced anaphylaxis which is a rapid potentially life threatening reaction can occur in more serious cases Despite the s ...

DESCRIPTION provided by applicant KDH Research andamp Communication KDHRC proposes to develop and evaluate Dientes Fuertes Vida Sana DFVS a culturally competent program to prevent primary tooth decay in low income Latino children ages zero to six To effectively reach low income Latino children DFVS will train promotores de salud PS at Latino serving community based organizations CBO ...

DESCRIPTION provided by applicant In recent years there has been increased interest throughout the world in the use of proton radiation therapy for treatment of cancer and independent studies project a annual increase in the installed base The replacement of X ray therapy with proton therapy will have substantial long term benefit to patients due to greatly reduced long and short term tox ...