Award Data

Environmental studies have proven that ammonia (NH3) presents a significant environmental hazard; therefore, accurate monitoring and control of NH3 concentration is required inorder to maintain appropriate air quality levels. Atmospheric ammonia contributes directly and indirectly to acidification, eutrophication, human health and climate change. For air pollution monitoring, the ammonia concentr ...

DESCRIPTION (provided by applicant): Treatment of peripheral pain of various origins remains a major unmet medical need, affecting tens to hundreds of millions of people nationwide at some time during their lives. Kappa-opioid agonists have been shown in peripheral pain models to be particularly efficacious but suffer from centrally mediated effects that have limited their development. Perhaps the ...

DESCRIPTION (provided by applicant): Neuropathic pain management is a major unmet clinical need. Classically used medications, including opioids and non-opioids (primarily NSAIDs), have major side effects associated with their use, and many individuals donot respond to any medications. Neuropathic pain drugs with novel mechanisms of action are being sought as an alternative; however, the only succ ...

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a safe and efficacious therapeutic small molecule for treatment of acute kidney injury (AKI). AKI results from diverse insults such as sepsis, ischemia-reperfusion (I/R)or nephrotoxicant exposure and nearly half of those who develop AKI do not survive. Since treatment remains largely palliative and survival rates ...

DESCRIPTION (provided by applicant): This Phase I project is motivated by current issues associated with screening for retinopathy of prematurity (ROP). ROP is the leading cause of blindness in infants. In recent years the number of infants at risk for ROPhas been increasing. In the United States, the rate of prematurity has risen from 9.4% of all births in 1981 to 12% in 2010, for a total of over ...

Summary Teleretinal programs have expanded in recent years, primarily to screen for diabetic retinopathy. Accurate and consistent assessment of the retinal vasculature, which often sustains damage as a result of cardiovascular disease, would advance teleretinal screening in terms of robustness and cost. Unfortunately, assessing changes to the retinal vasculature and quantifying abnormalities in re ...

DESCRIPTION (provided by applicant): Storage of cells for many researchers simply involves addition of 10% DMSO or similar cryoprotectants to cells in suspension, putting them in cryovials and slow cooling to subzero temperaturesf and storage in a mechanical or nitrogen cooled freezer or dewar. As long as viable cells are present upon thawing, cell yield may be a secondary consideration due to the ...

DESCRIPTION (provided by applicant): Hernia repair is one of the most frequently performed surgical operations in the United States with approximately 800,000 procedures performed annually. The vast majority of these repairs employ a tension- free repairtechnique which involves the use of synthetic surgical meshes. Existing mesh technology is designed to be of high strength to produce a perceive ...

DESCRIPTION (provided by applicant): Summary/Abstract It has been estimated that in the United States spastic hemiplegia cerebral palsy occurs in 1 out every 1000 births. Affected children typically have one hand with compromised positioning and limited function. While they frequently have the ability to initiate grasping and open the fingers, the affected hand is often maintained with a thumb-in- ...

DESCRIPTION (provided by applicant): Diabetes among Hispanics has reached epidemic proportions. (1) [Pre-diabetes] education is key in diabetes prevention and control yet education tools that translate into culturally engaging, yet simple and easy to understand information is a challenge for Hispanics. Limited health literacy, lack of English-language proficiency, trouble accessing healthcare and ...