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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of Peptide Antibiotic Nucleic Acids

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. In vivo conjugated multivalent toxoid-polysaccharide vaccine for S. aureus

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Staphylococcus aureus is a Gram positive human pathogen that causes a wide range of infections from skin and soft tissue infections SSTI to life threatening sepsis and pneumonia The pathogenicity of S aureus is dependent on numerous virulence factors including cell surface proteins and polysaccharides as well as secreted toxins An important group of thes ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Automating mosquito microdissection for a malaria PfSPZ vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION Malaria causes andgt million clinical cases and million deaths annually is responsible for andgt loss of GDP in Africa and is a serious concern for travelers and military personnel A highly effective vaccine is desperately needed and radiation attenuated Plasmodium falciparum Pf sporozoites SPZ and non attenuated PfSPZ with chloroquine chemoprophylaxis ChemoProphylax ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Long-term anti-angiogenic activity of intravitreal ellipsoid particles for NVAMD

    SBC: Asclepix Therapeutics, Inc.            Topic: N

    DESCRIPTION provided by applicant Long term anti angiogenic activity of intravitreal ellipsoid particles for NVAMD Niranjan B Pandey Ph D PI Aleksander S Popel Ph D Co I Jordan J Green Ph D Co I Peter A Campochiaro M D Co I of subaward Project Summary Current therapies for wet age related macular degeneration AMD target vascular endothelial growth factors VEGFA and pla ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting endogenous sialidases for treatment of endotoxic shock

    SBC: Oncoimmune Inc            Topic: NIAID

    DESCRIPTION provided by applicant Despite the advance of antibiotics sepsis remains a major challenge to human health as both survival and incidence of severe sepsis have been largely unchanged in the last two decades It is therefore important to develop new therapeutic approaches We have recently reported that bacterial sialidases may serve as therapeutic targets for polybacterial sepsis H ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Laser Speckle Imaging Chip for Telehealth Applications

    SBC: Vasoptic Medical, Inc.            Topic: NIA

    DESCRIPTION provided by applicant There is a strong unmet need for a low cost and convenient technology that can assist researchers and healthcare personnel in gathering vascular data Such vascular imaging technology could assist in the short term clinica research on the diagnostics disease progression and effect of treatment prevention strategies ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Therapeutic/preventive vaccination against MusPV

    SBC: PAPIVAX, LLC            Topic: NIAID

    DESCRIPTION provided by applicant While most human papillomavirus HPV infections are short lived a subset become chronic and can progress to malignancy with much greater frequency in HIV infected individuals Only a dozen andapos high riskandapos HPV types cause cancer but HPV alone is responsible for andgt of anal cancer head and neck cancer and of cervical cancer Further and ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Twist-Sensor: Novel microarrays for multiplex detection of drug resistance

    SBC: SCANOGEN INC.            Topic: NIAID

    DESCRIPTION provided by applicant Drug resistance is rapidly spreading among Gram negative bacteria seriously complicating the treatment of infected patients and increasing the risk of lethal outbreaks In particular carbapenem resistant Enterobacteriaceae CRE organisms associated with high mortality rate andgt have become prevalent worldwide During of long term acute car ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Novel microarrays for DNA genotyping in the presence of excess background DNA

    SBC: SCANOGEN INC.            Topic: 172

    DESCRIPTION provided by applicant DNA microarrays are a primary tool for DNA genotyping because of their capacity to detect multiple targets simultaneously However DNA microarrays require fluorescent labeling and long incubation steps which limit their applicability Furthermore DNA microarrays are not capable of detecting DNA targets in the presence of excess background DNA This capacity ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Enhancing Augmentative and Alternative Communication Rates in pre-K Through 6

    SBC: Speak Agent, Inc.            Topic: N/A

    The project team is developing a prototype of a tool for touch-screen mobile devices to support students in pre-kindergarten to grade 6 who have special communication needs. The product will include artificial intelligence software that will adapt the prompts and cues to the needs of individual students. In the Phase I pilot research, the team will examine whether the prototype functions as planne ...

    SBIR Phase I 2014 Department of Education
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