Award Data

DESCRIPTION (provided by applicant): Large insert DNA libraries are essential for the molecular analysis of the human genome and other genomes important to our well-being. Comparative genomics reveals new information about metabolic pathways, cancer, horizontal gene transfer, evolution, protein families, and the genetic repertoire of numerous species. It has also greatly increased the demand for a ...

DESCRIPTION (provided by applicant): Most drugs interact with protein molecules to elicit a cellular response. Traditional drug discovery is a laborious and expensive experimental process, so computational approaches to assess protein function and to accelerate the discovery process are in high demand. Virtual drug screening and structure-based drug design represent computational approaches that c ...

DESCRIPTION (provided by applicant): This Phase II SBIR grant will enable the continued development of a unique and comprehensive research resource, the Protein Catabolism Database (PCDB), which will enable scientists to build upon a wealth of information to accelerate basic research and drug target identification. PCDB focuses on the field of protein catabolism, aberrations of which are implicate ...

DESCRIPTION (provided by applicant): The primary goal of this Phase I project is to test the feasibility of a computerized diagnostic tool for collaborative assessment of psychiatric disorders in children and adolescents. Such a system is sorely needed in both clinical and research settings because (a) structured clinical interviews, although the gold standard in diagnosis, are time consuming an ...

DESCRIPTION (provided by applicant): Limb-shortening deformities and bone segmental defects remain among the most difficult challenges faced by patients and orthopaedists. Traditional techniques to correct these problems rely primarily on transverse pins or wires, which are subject to pain, scars, contractions, and risk of infection. The Phase I research demonstrated the feasibility of a new metho ...

Abstract Alcohol and illicit drug use remain highly prevalent in the US, and epidemiological surveillance surveys estimate that over 20.6 million individuals (~ 8% of the US population) meet standard diagnostic thresholds for substance use disorders (SAMHSA, 2011). Outpatient substance abuse treatment is the predominate method of treatment in the US for SUDs, typically involving intermittent cont ...

DESCRIPTION (provided by applicant): Patient-centered care recognizes patients' desires, opinions, and preferences as equal in importance to those of healthcare professionals, and emphasizes the need to educate and empower patients to play an active role in their care. The achievement of patient-centered care is associated with increased patient and provider satisfaction, improved health outc ...

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ABSTRACT: Autonomous vehicles lack a standardized mechanism for seamless cross-platform sharing of testing frameworks and evaluations of basic tasks. The ability to execute common tests on various hardware platforms is essential in order to be able to e

The goal of this project is to create a high throughput, sensitive, quantitative and cost-effective platform for measuring gene expression in response to natural compounds derived from foods -nutraceuticals. This technology, the RNA InvaderTM assay, offers highly sensitive detection of mRNA messages directly from cell lysates without the need for reverse transcription or target amplification. We ...