Award Data

ABSTRACT. Peripheral nerve injury (PNI) is a common and challenging clinical problem affecting over 3% of U.S. trauma patients. Among combat trauma, the rate of PNI increases to 22%. These patients require extensive resources for initial treatment and therapy, yet they are still left with functional disability. Current treatments for motor, sensory, and mixed PNI include nerve autografts and axona ...

PROJECT SUMMARY/ABSTRACT Posttraumatic Stress Disorder (PTSD) is a debilitating disease affecting millions of American military veterans and civilians. Prolonged Exposure (PE) therapy is evidence-based and effective but limited by high dropout rates and incomplete resolution of symptoms in approximately one-third of patients. A crucial component of PE, as well as interventions for anxiety disorder ...

Project Summary The goal of this project is to commercialize a novel, immunologically-enhanced version of Lactobacillus acidophilus for the treatment of inflammatory bowel disease (IBD). Over 1.6 million adults and children in the United States suffer from IBD, an umbrella term encompassing two chronic inflammatory diseases of the gastrointestinal tract: Crohnandapos;s disease (CD) and ulcerative ...

Project abstract/summary This proposal responds to the NIH PA-16-157 “New Technologies for the Glycosciences (R43/R44)”. We aim to develop efficient and streamlined cheomoenzymatic systems for glycan remodeling of antibodies and other important glycoproteins, through optimizing enzyme immobilization and simplifying the reaction procedures. Such immobilized enzymes, when combined with activated ...

PROJECT SUMMARY/ABSTRACT In this competitive revision Phase I SBIR, Gryphon Scientific proposes to expand the scope of the ongoing project to support the urgent need to develop and deploy training for first responder populations at risk of exposure to the novel coronavirus (COVID-19). The ongoing Phase I SBIR project focuses on training first responders (including law enforcement, fire, and EMS pe ...

Project summary Filoviruses are among the deadliest known human viruses. The family Filoviridae contains two clinically relevant genera; Ebolavirus and Marburgvirus that each consist of multiple viruses. Filoviruses have caused 48 outbreaks since Marburg virus was discovered in 1967. Marburgvirus has caused 13 outbreaks, 5 of which occurred in the past 10 years with an average lethality of 81%. Th ...

PROJECT SUMMARYThe threat of a nuclear attack or disaster resulting in mass casualties is of increasing concernRadiation injury frequently occurs in combination with thermal burnsCombined radiation and thermal burn injuryCRBIresults in impaired wound healingexacerbated symptomsand synergistic increases in mortalityCountermeasures that synergistically address the complex pathophysiology of CRBI at ...

Project Summary Abstract Covalent drug discovery is gaining increasing interest and clinical successespecially for cancer and infectious diseasesAlthough old covalent drugs were discovered serendipitouslymodern covalent drug discovery takes a rational approachWhile chemical intuition and trial and error are helpfulthe discovery process can be signi cantly shortened by the knowledge of whether the ...

AbstractMethicillin resistant Staphylococcus aureusMRSAis one of the leading causes of many life threatening infections such as skin and soft tissue sepsispneumoniaosteomyelitis and endocarditisDue to the growing incidence of multiple drug resistance in Saureus strains and the absence of effective new antibioticstreatment options are becoming increasingly limitedDifficulties in developing new anti ...

Project Summary Many bacterial pathogens secrete exotoxins to modify the host-pathogen interactions in a manner that benefits the bacteria. There are several examples of successful prophylaxis and treatment by targeting bacterial toxins as evident by decades-long history of vaccines for tetanus, diphtheria, and pertussis. Staphylococcus aureus (SA) is a major human pathogen responsible for several ...