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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. OPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

    SBC: Alcamena Stem cell Therapeutics, LLC            Topic: NINDS

    ABSTRACT. Peripheral nerve injury (PNI) is a common and challenging clinical problem affecting over 3% of U.S. trauma patients. Among combat trauma, the rate of PNI increases to 22%. These patients require extensive resources for initial treatment and therapy, yet they are still left with functional disability. Current treatments for motor, sensory, and mixed PNI include nerve autografts and axona ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Intelligent Biometrics to Optimize Prolonged Exposure Treatment for PTSD (IB-PE)

    SBC: Zeriscope, Inc.            Topic: 104

    PROJECT SUMMARY/ABSTRACT Posttraumatic Stress Disorder (PTSD) is a debilitating disease affecting millions of American military veterans and civilians. Prolonged Exposure (PE) therapy is evidence-based and effective but limited by high dropout rates and incomplete resolution of symptoms in approximately one-third of patients. A crucial component of PE, as well as interventions for anxiety disorder ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Probiotic Engineered for Enhanced Immunological Function for Treating Inflammatory Bowel Disease

    SBC: Rise Therapeutics, LLC            Topic: NIAID

    Project Summary The goal of this project is to commercialize a novel, immunologically-enhanced version of Lactobacillus acidophilus for the treatment of inflammatory bowel disease (IBD). Over 1.6 million adults and children in the United States suffer from IBD, an umbrella term encompassing two chronic inflammatory diseases of the gastrointestinal tract: Crohnandapos;s disease (CD) and ulcerative ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of streamlined chemoenzymatic glycan remodeling systems for antibodies and other important glycoproteins

    SBC: Glycot Therapeutics, LLC            Topic: 300

    Project abstract/summary This proposal responds to the NIH PA-16-157 “New Technologies for the Glycosciences (R43/R44)”. We aim to develop efficient and streamlined cheomoenzymatic systems for glycan remodeling of antibodies and other important glycoproteins, through optimizing enzyme immobilization and simplifying the reaction procedures. Such immobilized enzymes, when combined with activated ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of A Narrow Spectrum Anti-Tubercular Agent

    SBC: L2 Diagnostics, LLC            Topic: NIAID

    Abstract Complex and lengthy treatment regimens coupled with rising drug resistance underscore the urgent need for new and better drugs to treat tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis (Mtb). Current treatment regimens for drug resistant TB involve the use of costly, less effective, and toxic drugs that must be continued for up to 24 months. The work proposed here focu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Monoclonal antibodies targeting novel sites of vulnerability in marburg virus glycoprotein

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Filoviruses, consisting of two major virus families including the ebolaviruses and marburgviruses (MARV and RAVV), cause periodic outbreaks of severe viral hemorrhagic fever with mortality rates as high as 90%. Since it is difficult to predict the species that would dominate future outbreaks, development of broadly protective therapeutics to prevent and manage future filovirus outbreaks is of high ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Targets of Acquired Tick-Resistance As Anti-Tick Vaccines

    SBC: L2 Diagnostics, LLC            Topic: NIAID

    ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tick, Ixodes scapularis, by targeting tick salivary proteins (Salps) critical for tick feeding. I. scapularis Salps provide functions critical for evading host defense responses detrimental to the tick. Further, these salivary functions are also co-opted by tick-transmitted pathogens to ensure t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Custom-Fit Personal Sound Amplification Smartphone Application

    SBC: ASCENDING HEARING TECHNOLOGIES, LLC            Topic: NIDCD

    PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A novel asthma drug candidate targeting the GABAergic system in lung inflammation

    SBC: PANTHERICS INCORPORATED            Topic: NHLBI

    The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Preventing Opioid Exposure Training (POET) for First Responders

    SBC: GRYPHON SCIENTIFIC, LLC            Topic: 142

    PROJECT SUMMARY/ABSTRACT In this competitive revision Phase I SBIR, Gryphon Scientific proposes to expand the scope of the ongoing project to support the urgent need to develop and deploy training for first responder populations at risk of exposure to the novel coronavirus (COVID-19). The ongoing Phase I SBIR project focuses on training first responders (including law enforcement, fire, and EMS pe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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