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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Highly specific HIV mRNA detection method with global subtype coverage to monitor latency reversal in patients

    SBC: Accelevir Diagnostics, LLC            Topic: NIAID

    Project Summary Abstract Human immunodeficiency virus type HIV is a retrovirus that infects CD T cells of the immune system If left untreated HIV infected individuals will progress to AIDS and may ultimately die as a result Combination antiretroviral therapy is extremely effective at stopping the replication of HIV in infected individuals Despite the success of this therapy at sup ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development and Commercialization of Predictive Biomarker Panel and In Office Kit for the Management of Diabetic Macular Edema

    SBC: OCULAR PROTEOMICS, LLC            Topic: N

    Abstract Diabetic Macular Edema DME is a vision threatening stage in Diabetic Retinopathy DR that can result in legal blindness The biochemical mechanisms that drive DME progression are not well understood and treatments address only portions of the disease pathology The available treatment options vary widely from injectable anti VEGF to injectable steroids to laser treatments and carry a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. In Vivo Editing for Hemophilia Gene Therapy

    SBC: GENVEC, INC.            Topic: 100

    Project Summary The exceptional promise of gene therapy for hemophilia has been shown in recent studies that result in long term correction of factor IX deficiency via hepatic transduction with an adeno associated vector AAV In spite of this watershed event in the history of the gene therapy field there presently exist barriers to the fullest implementation of hemophilia gene therapy The li ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Systematic Medical Approach to Reward Transformation SMART for Brain Health in Opioid Use Disorder

    SBC: Versa Integrated Solutions, Inc.            Topic: 102

    Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes Abstract There has been explosive growth in interest in Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS over the past five years because it has demonstrated S N gains exceeding two orders of magnitude at K compared to conventional MAS NMR and non spinning NMR of biological macro ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Single Chain Antibodies against MIF for Prostate Cancer Therapy

    SBC: Ibex Biosciences, LLC            Topic: 102

    With the help of the National Cancer Institute we at Ibex Biosciences propose the following Phase SBIR project to evaluate novel camelid VHH antibodies that target macrophage migration inhibitory factor MIF for the treatment of solid tumors MIF is known to play prominent roles in the development of cancer and its expression in humans has shown to correlate with prostate cancer severity ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Targeted Nanomedicine Delivering MicroRNA-30-5p ReplacementTherapy for Multi-drug Resistant Cancer Treatment

    SBC: Mirecule, Inc.            Topic: NCI

    AbstractIn this SBIR application miRecule proposes to develop a microRNA based therapeutic mimic of miRpmiRecule candidate MCfor the treatment of multi drug resistantMDRcancersHead and Neck Squamous Cell CarcinomaHNSCCis theth most common form of cancerGreater than half of patients present with late stage III or IV diseasewith an averageyear survival rate ofHNSCC tumors have high levels of genetic ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Assessing Skills and Treatment Progress in Basic Communicators of All Ages The Basic Social and Communication Behavior Scales BSCBS Phase I

    SBC: PAUL H BROOKES PUBLISHING CO., INC.            Topic: NIDCD

    Project Summary Abstract Effective communication intervention depends on reliable tools for identifying communication concerns and tracking changes in skills Established tools for detecting and tracking skills in early intentional communicators i e directing a behavior such as reaching toward an adult to convey a message involve communication temptations and assessing a wide variety of child ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a companion diagnostic to predict response to cetuximab in patients with head and neck squamous cell carcinoma

    SBC: Biomarker Strategies, LLC            Topic: 100

    ABSTRACT Head and neck squamous cell carcinoma HNSCC is the world s th leading cause of cancer accounting for of cancer mortality For many other cancers molecular characterization has led to sub classification of disease based on the status of oncogenic drivers in signal transduction pathways leading to the development of molecularly targeted agents MTAs targeting specific dysregulate ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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