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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. OPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

    SBC: Alcamena Stem cell Therapeutics, LLC            Topic: NINDS

    ABSTRACTPeripheral nerve injuryPNIis a common and challenging clinical problem affecting overof U Strauma patientsAmong combat traumathe rate of PNI increases toThese patients require extensive resources for initial treatment and therapyyet they are still left with functional disabilityCurrent treatments for motorsensoryand mixed PNI include nerve autografts and axonal guidance tubesHoweverthese m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Intelligent Biometrics to Optimize Prolonged Exposure Treatment for PTSD (IB-PE)

    SBC: Zeriscope, Inc.            Topic: 104

    PROJECT SUMMARY ABSTRACT Posttraumatic Stress DisorderPTSDis a debilitating disease affecting millions of American military veterans and civiliansProlonged ExposurePEtherapy is evidence based and effective but limited by high dropout rates and incomplete resolution of symptoms in approximately one third of patientsA crucial component of PEas well as interventions for anxiety disordersisIn Vivo Exp ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Probiotic Engineered for Enhanced Immunological Function for Treating Inflammatory Bowel Disease

    SBC: Rise Therapeutics, LLC            Topic: NIAID

    Project Summary The goal of this project is to commercialize a novelimmunologically enhanced version of Lactobacillus acidophilus for the treatment of inflammatory bowel diseaseIBDOvermillion adults and children in the United States suffer from IBDan umbrella term encompassing two chronic inflammatory diseases of the gastrointestinal tractCrohnandapos s diseaseCDand ulcerative colitisUCIBD is typi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of streamlined chemoenzymatic glycan remodeling systems for antibodies and other important glycoproteins

    SBC: Glycot Therapeutics, LLC            Topic: 300

    Project abstract summary This proposal responds to the NIH PANew Technologies for the GlycosciencesRRWe aim to develop efficient and streamlined cheomoenzymatic systems for glycan remodeling of antibodies and other important glycoproteinsthrough optimizing enzyme immobilization and simplifying the reaction proceduresSuch immobilized enzymeswhen combined with activated glycan library as kitscan hel ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Monoclonal antibodies targeting novel sites of vulnerability in marburg virus glycoprotein

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Filovirusesconsisting of two major virus families including the ebolaviruses and marburgvirusesMARV and RAVVcause periodic outbreaks of severe viral hemorrhagic fever with mortality rates as high asSince it is difficult to predict the species that would dominate future outbreaksdevelopment of broadly protective therapeutics to prevent and manage future filovirus outbreaks is of high priorityIn sha ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Preventing Opioid Exposure Training (POET) for First Responders

    SBC: GRYPHON SCIENTIFIC, LLC            Topic: 142

    PROJECT SUMMARY ABSTRACT The United States opioid crisisreferring to the rapid increase in thes of both prescription and non prescription opioid abuse in the United Statesis a major public health issuewith overdose deaths from opioids reaching epidemic levelssurpassing the number of gun related deaths inWhile heroin remains the main illicit opioid abused in the U Sa recent dramatic increase in the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Mining natively paired macque antibodies for Marburg virus protective antibodies

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Project summary Filoviruses are among the deadliest known human virusesThe family Filoviridae contains two clinically relevant generaEbolavirus and Marburgvirus that each consist of multiple virusesFiloviruses have causedoutbreaks since Marburg virus was discovered inMarburgvirus has causedoutbreaksof which occurred in the pastyears with an average lethality ofThe recent outbreak of Ebola virus di ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Evaluation of a Novel Connexin-Based Peptide in the Treatment of Combined Ionizing Radiation and Thermal Burn Injury

    SBC: FirstString Research, Inc            Topic: NIAID

    PROJECT SUMMARYThe threat of a nuclear attack or disaster resulting in mass casualties is of increasing concernRadiation injury frequently occurs in combination with thermal burnsCombined radiation and thermal burn injuryCRBIresults in impaired wound healingexacerbated symptomsand synergistic increases in mortalityCountermeasures that synergistically address the complex pathophysiology of CRBI at ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Cloud-Based Web Application to Accelerate Targeted Covalent Drug Discovery

    SBC: ComputChem LLC            Topic: 400

    Project Summary Abstract Covalent drug discovery is gaining increasing interest and clinical successespecially for cancer and infectious diseasesAlthough old covalent drugs were discovered serendipitouslymodern covalent drug discovery takes a rational approachWhile chemical intuition and trial and error are helpfulthe discovery process can be signi cantly shortened by the knowledge of whether the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Whole-Cell Vaccine Development for MRSA

    SBC: BIOLOGICAL MIMETICS, INC.            Topic: NIAID

    AbstractMethicillin resistant Staphylococcus aureusMRSAis one of the leading causes of many life threatening infections such as skin and soft tissue sepsispneumoniaosteomyelitis and endocarditisDue to the growing incidence of multiple drug resistance in Saureus strains and the absence of effective new antibioticstreatment options are becoming increasingly limitedDifficulties in developing new anti ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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