Award Data

DESCRIPTION (provided by applicant): This Phase I proposal seeks support to evaluate the feasibility of developing an extracellular matrix (ECM) biologic scaffold as a repair device for atrial septal defects (ASD). ASDs are one of the most common forms of congenital heart disease and account for approximately 30-40% of all congenital heart defects seen in adults. Closure of an ASD can be performed ...

DESCRIPTION (provided by applicant): The ability to culture human embryonic stem cells generated a great deal of excitement about their vast potential for treating a variety of human diseases such as diabetes, heart disease, neurological, retinal and skin disorders to name a few. Unlike adult stem cells, embryonic stem cells have indefinite growth potential and the potential to develop into any t ...

This Small Business Innovation Research Phase I project is focused on the development of a unique, high efficiency cold plate technology for application to Insulated Gate Bipolar Transistors (IGBT) modules. The cold plate is enabled by a dielectric-graphite-metal composite material which serves as the cold plate's lid and provides for electric isolation of the electronic components and circuitry, ...

This Small Business Innovation Research (SBIR) Phase I project is focused on the development of unique, graphite-organic matrix materials for application as a thermal interface material (TIM) for use in high power electronics packaging. The research objective of this project is the development of an understanding of the relationship between the physical design of the proposed graphite-organic TIM ...

DESCRIPTION (provided by applicant): Pancreatic adenocarcinoma is the fourth leading cause of cancer deaths in the US; with less than one-year median survival, it accounts for approximately 30,000 diagnoses and deaths per year. Multimodality therapy, including surgery, radiation and chemotherapy, have not made a significant impact on the outcome and serve mostly as palliation. Thus, new treatment ...

The complexity of Atmospheric Transport and Dispersion (ATD) modeling requires physically consistent weather data evolving in both space and time. Spatially and/or temporally averaged data found in climatological products is not suitable for ATD modeling. The proposed solution for providing “typical day” meteorological data couples innovative search techniques applied to long-range historical ...

Atmospheric and Environmental Research, Inc. proposes to develop a prototype threat-reduction system for the dispersion of a weapons-of-mass destruction warhead in the upper atmosphere. Our system will extend current DTRA atmospheric transport and dispersion capabilities into the 20-120 km altitude region. This will be accomplished using a combination of a zonally-averaged transport model of the s ...

Acrolein (CH2=CHCHO) has been identified by the U.S. Clean Air Act as a hazardous air pollutant because of its adverse health effect, particularly on respiratory systems. There are both anthropogenic and natural sources of acrolein in the environment. Acrolein is produced by combustion sources (e.g. vehicle exhaust, prescribed agricultural burning, cigarette smoke) and industrial sources, includi ...

This Small Business Technology Transfer (STTR) Phase I Project concerns the development of field-based analytical instrumentation for the determination of carbon content in soil. The instrumentation will employ laser-induced breakdown spectroscopy utilizing detection of atomic carbon ultraviolet emission. The work plan will focus on a proof-of-principle demonstration using standard soil samples as ...

This Small Business Innovation Research (SBIR) Phase I research project will produce corn with processing traits optimized for ethanol production. The corn will be modified by embedding inactive amylase enzymes into the crop that can be activated during processing steps. The polysaccharide degrading activity of the enzymes can be switched on after harvest, resulting in controllable, accelerated li ...