Award Data

Project Summary Embryonic stem cells offer considerable potential for cell replacement therapy where cells have been lost to injury or disease because of their capacity for continual self renewal and ability to differentiate into virtually any cell type or tissue. Currently, however the process by which human embryonic stem cells (hESCs) differentiate into various mature functional cell types is ...

DESCRIPTION (provided by applicant): Sufficient general clinical knowledge, DNA sequence technology and understanding of genetic mutations for over 2,600 human genes can support beginning the integration of individual genome sequence into clinical practic e for a number of medical specialties. With the 2007 deployment of novel DNA sequence technologies that permit cost-effective interrogation of ...

DESCRIPTION (provided by applicant): Real-Time Image and Dose Guided Radiation Therapy System Development and integration of a real-time image- and dose-guided radiation therapy system is long overdue. Advanced Radiation Therapy has identified an opportuni ty and designed a single system that uses a common platform for imaging the target tissue in real-time, immobilizing the tissue, delivering rad ...

Ammonia has an important role in the chemistry of the atmospheric environment and air quality. Ammonia emissions are a major environmental concern, yet they remain poorly quantified. There is a need for a sensitive ammonia instrument to monitor emissions and evaluate their effects on the local and regional environments. An instrument capable of continuous monitoring is required to understand diurn ...

DESCRIPTION (provided by applicant): Signal transduction systems regulate the majority of cellular activities including the metabolism, development, host-recognition, biofilm production, virulence, and antibiotic resistance of human pathogens. Thus, knowle dge of the proteins and interactions that comprise these communication networks is an essential component to furthering biomedical discovery. T ...

Recent materials development together with an improving understanding of organic transistors has enabled solution-processed materials that show good performance, with high transparency in the visible range. In this program, leveraging on our extensive experience in organic material development and large scale organic material deposition by solution based processing, AGILTRON and Stanford Universit ...

Infrared (IR) imaging is the best method for detecting leaks of pollutant gases, but current technology based on cooled IR imagers is far too expensive ($75,000 to $150,000) for everyday field use by those who need it to meet regulatory limits¿electric and petrochemical utilities, manufacturing plants, and businesses such as supermarkets. Agiltron will demonstrate a new class of IR imager instrum ...

Until now gamma radiation detection has required large single crystals of sensitive materials that are difficult to produce consistently on an industrial scale. In collaboration with a research group at the University of Texas at Arlington, Agiltron proposes to develop a new class of nanocomposite scintillator materials. The radiation detection characteristics of the synthetic nanoparticles in the ...

DESCRIPTION (provided by applicant): Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells and are capable of manipulating nanoliter samples of reagents and solvents. The microfluidic chips have been designed for a multitude of applicati ...

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) imaging systems used in Nuclear Medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- in teraction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them ...