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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Optimization of Arenavirus Antivirals

    SBC: Arisan Therapeutics, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Seven distinct arenavirus species have been associated with arenaviral hemorrhagic fevers AVHF in humans with case fatality rates as high as Human infection with arenaviruses typically occurs through contact with materials contaminated with the excretions of an infected rodent although direct human to human transmission often occurs in clinical settings ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Mitochondrial Antioxidant Neurodegenerative Therapeutics: XJB-5-131 Derivatives

    SBC: SOLANO PHARMACEUTICALS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Oxidative damage to mitochondrial is a major source of toxicity in diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD). Mitochondria are energy powerhouses of the cell, and decline in their function by oxidative damage is a common feature among neurodegenerative diseases. Despite years of effort, however, generic ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Development of selective Cav3 channel blockers for treatment of neuropathic pain

    SBC: AFASCI, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Millions of Americans suffer from chronic neuropathic pain, which is often refractory to current treatment. In search of a solution to this problem of chronic, untreatable pain, we intend to develop a new analgesic therapy based on modulation of the T-type Ca2+ channel. T-type Ca2+ channels play key roles in pain signaling. The Cav3 family of channels is invo ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Enzyme Switch: many reporter molecules from a single-molecule-sequencing product

    SBC: CAERUS MOLECULAR DIAGNOSTICS INCORPORATED            Topic: NHGRI

    DESCRIPTION provided by applicant Even as the cost and throughput of commercial sequencers has continued to improve over the last years there is still a need to further reduce sequencing costs to increase throughput and sequencing accuracy and to reduce the costs associated with sample preparation Single molecule methods such as the Pacific Biosciences or nanopore technologies have the pot ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. I-Corp Customer Discovery of Automated Wireless Microinfusion Systems

    SBC: FLUID SYNCHRONY, LLC            Topic: 300

    DESCRIPTION provided by applicant Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station Automation of drug administration and on demand dose adjustment in freely moving animals offers greater throughput and improved outcomes compared to existing technologies Towards this end this proposal focus ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. RASL-Seq CTC Assay

    SBC: BioSpyder Technologies, Inc.            Topic: 172

    DESCRIPTION provided by applicant This project will demonstrate the feasibility of identifying circulating tumor cells CTCs that have undergone an epithelial mesenchymal transition EMT by profiling a gene expression signature using a targeted sequencing platform the RASL Seq assay The presence of CTCs that have undergone EMT is prognostic of poor long term survival The gene profile will ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer's Disease

    SBC: Newomics Inc            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is a devastating neurodegenerative disease that affects more than million people including million Americans worldwide and this number is expected to reach more than million by the year Recent disappointing clinical trials of bapineuzumab and solanezumab in AD treatment further aggravate the problem There is cu ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Biomechanical enrichment of malignant cells enabling companion diagnostics

    SBC: CytoVale, Inc            Topic: NIBIB

    DESCRIPTION provided by applicant The rise in using companion diagnostics to guide selection of pharmacological agents in cancer treatment has led to a need for technologies which can extend these diagnostics to additional patients with difficult to access tumors Such diagnostic assays are performed on cells extracted from tumors or metastatic cells found distant from the primary tumor site E ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Comprehensive Genomic Sample Prep Based on Lateral Ultrasonic Wave Transducer

    SBC: MICROSONIC SYSTEMS INC            Topic: 172

    DESCRIPTION provided by applicant Genetic analysis is the driving force behind andquot Personalized Medicineandquot and has become an essential tool in advancing all areas of biology medicine and behavioral biology This project will provide instrumentation to streamline sample preparation needed for genetic sequence analysis Currently multiple instruments are used in sample preparation fo ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

    SBC: Posit Science Corporation            Topic: NIA

    DESCRIPTION provided by applicant The primary objective of the current project is to develop and evaluate the efficacy of on line brain plasticity based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimerandapos s disease AD This novel therapeutic strategy is designed to re connect and reinvigorate Default Network DN brain areas by in ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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