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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Enzyme Switch: many reporter molecules from a single-molecule-sequencing product

    SBC: CAERUS MOLECULAR DIAGNOSTICS INCORPORATED            Topic: NHGRI

    DESCRIPTION provided by applicant Even as the cost and throughput of commercial sequencers has continued to improve over the last years there is still a need to further reduce sequencing costs to increase throughput and sequencing accuracy and to reduce the costs associated with sample preparation Single molecule methods such as the Pacific Biosciences or nanopore technologies have the pot ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Novel caveolin modulators as therapeutics for uveitis

    SBC: E AND B TECHNOLOGIES, LLC            Topic: N

    DESCRIPTION provided by applicant Novel caveolin modulators as therapeutics for uveitis Project Summary This research proposal seeks to develop a novel therapy for uveitis based upon modulation of inflammatory signaling via caveolae Uveitis drives of blindness affecting people of working age and producing significant disability in patients with chronic disease Caveolin modulators such ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. I-Corp Customer Discovery of Automated Wireless Microinfusion Systems

    SBC: FLUID SYNCHRONY, LLC            Topic: 300

    DESCRIPTION provided by applicant Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station Automation of drug administration and on demand dose adjustment in freely moving animals offers greater throughput and improved outcomes compared to existing technologies Towards this end this proposal focus ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Sample Pretreatment for Human Fluids

    SBC: Sonata Biosciences Inc            Topic: 400

    DESCRIPTION provided by applicant In this proposal we seek to develop a new method and instrument to reduce the complexity of protein mixtures derived from human fluids with an eye to discovery of very low abundance protein biomarkers The proposed method accomplishes two tasks it reduces the dynamic range of the protein mixture by three or more orders of magnitude and it concentrates proteins ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Peptide Antibiotic Nucleic Acids

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

    SBC: Posit Science Corporation            Topic: NIA

    DESCRIPTION provided by applicant The primary objective of the current project is to develop and evaluate the efficacy of on line brain plasticity based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimerandapos s disease AD This novel therapeutic strategy is designed to re connect and reinvigorate Default Network DN brain areas by in ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. MicroRNA-Based Radiation Biodosimeter (MiRAD)

    SBC: Chromologic LLC            Topic: NIAID

    DESCRIPTION provided by applicant The broad long term goal of this project is to develop an optically based radiation biodosimeter that rapidly minutes measures changes in serological microRNA miRNA biomarkers to predict acute radiation syndrome ARS MicroRNAs miRNAs are short base non coding RNA strands that control a host of biological processes through regulation of pr ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Flavivirus Antivirals Targeting Dengue Virus and WNV Protease

    SBC: Plex Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Mosquito borne members of the Flavivirus family include four serotypes of dengue virus DENV and West Nile Virus WNV and are classified as re emerging pathogens due to the frequency and severity of recent epidemics There are an estimated million DENV infections reported each year resulting in nearly deaths More than billion people are at ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Inhibitors Targeting Early Steps of Human Cytomegalovirus Replication

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Human cytomegalovirus HCMV infection is a major cause of morbidity and mortality in immunosuppressed patients especially recipients of solid organ or bone marrow transplants HCMV infection of neonates is associated with deafness mental retardation and mortality Although five anti viral drugs GCV val GCV CDV PFA Foscarnet have been approved and lice ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer's Disease

    SBC: Newomics Inc            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is a devastating neurodegenerative disease that affects more than million people including million Americans worldwide and this number is expected to reach more than million by the year Recent disappointing clinical trials of bapineuzumab and solanezumab in AD treatment further aggravate the problem There is cu ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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