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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Therapeutic Intermittent Compression Socket
SBC: LIBERATING TECHNOLOGIES INC Topic: N/AThe purpose of this project is to develop a device that provides rapid intermittent compression to the residual limb of amputees that do not have good blood flow in their limbs. The device will be built into the prosthetic socket to provide the user with portable therapy throughout the day, which will free the user from being confined to a chair for up to six hours each day to receive the prescrib ...
SBIR Phase I 2014 Department of Education -
Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease
SBC: HEPROTECH, INC. Topic: NIAAA? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Clinically suitable approach for gene-mediated therapy of cirrhosis.
SBC: ADVANTAGENE, INC Topic: NIAAAAbstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Novel Algorithm for Free Testosterone Determination
SBC: FUNCTION PROMOTING THERAPIES LLC Topic: NIADESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Novel Compounds for Reducing Brain A-Beta Levels via Enhanced Systemic Clearance
SBC: AKSTON BIOSCIENCES CORPORATION Topic: NIADESCRIPTION (provided by applicant): Alzheimer's disease (AD) is characterized by progressively worsening dementia eventually leading to death. It affects over five million people in the United States and costs the healthcare system over 200 billion per year. Currently there is no available therapy for slowing, reversing or preventing the disease. There is strong evidence suggesting that AD ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Local Lymph Node Assay with IL-18 Endpoints
SBC: MB RESEARCH LABORATORIES, INC. Topic: NIAIDDESCRIPTION (provided by applicant): The current industry standard for predicting contact dermal sensitization is the murine Local Lymph Node Assay (LLNA). A significant limitation of the LLNA is the frequency of false positives, as well as the occurrenceof false negatives. This limitation occurs as a result of the LLNA inability to always correctly distinguish between substances that are strongly ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Novel therapeutic for hematopoietic stem cell regeneration in bone marrow post my
SBC: Minerva Biotechnologies Corporation Topic: NIAIDDESCRIPTION (provided by applicant): The purpose of this study is to establish in vivo proof of principle for a human therapeutic for hematopoietic stem cell regeneration in the bone marrow after myeloablation from radiation. Blood stem cells are the mostsusceptible to the effects of radiation and the most lethal. We have already demonstrated proof of principle for our therapeutic in vitro. If suc ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Ubiquitin pathway inhibitors for treatment of asthma
SBC: Progenra, Inc Topic: NIAIDDESCRIPTION (provided by applicant): Asthma is a chronic disease with considerable morbidity and no cures. Symptomatic treatment is efficacious but produces significant adverse effects. Thus, improved, targeted therapies for asthma are needed. Asthma develops when T cells (CD4+) differentiate to effector T cells, which secrete cytokines that assist in the recruitment and proliferation of various i ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
Host-Targeted Mechanism of Action for Treatment of Seasonal and Pandemic Influenz
SBC: EVRYS BIO LLC Topic: NIAIDDESCRIPTION (provided by applicant): Despite improvements in vaccine design, manufacture, and distribution, influenza A infection remains a significant public health concern. The February 2013 CDC Interim Adjusted Estimates of Seasonal Influenza Vaccine Effectiveness reported overall vaccine effectiveness of 56% and 67% against influenza A and B infections, respectively, with much reduced effect ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health -
A New Generation of Botulinum Toxin Vaccines
SBC: INVENTOX INC Topic: NIAIDDESCRIPTION (provided by applicant): Botulinum toxin is one of the six categories of pathogens that have been designated as Category A Select Agents by the Centers for Disease Control. The toxin, which is generally acknowledged to be the most potent biological poison known, enters the body and acts on peripheral cholinergic nerve endings to cause paralysis of transmission. In seriously poisoned pa ...
SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health