Award Data

This project will develop a prototype of a new component that supports classroom-based implementation of products in the library. The prototype will provide a mechanism for teachers to provide data on their experiences implementing technology products, and customized reports new teachers can use with results from prior teachers on how to best implement education technology. At the end of Phase I, ...

Bronchial asthma is a chronic respiratory disease that can be lethalAsthma is a global health problemAccording to the CDCin USAthere are currentlymillion asthma sufferers and this number is increasingHalf of the asthma patients have at least one hospitalization per yearwith an annual medical cost of $BTraditionallyasthma is treated during flare ups with prescribed inhaled corticosteriodsIn recent ...

The goal of this project is to fabricate a novel nanoscintillator photosensitizer complex for X ray excited photodynamic therapyXPDTHereina low dose of X raysltGyis used to excite scintillating nanoparticleswhich downconvert ionizing radiation to UV vis lightPhotosensitizers loaded onto the nanoscintillator complex absorb this UV vis emission and generate cytotoxic reactive oxygen speciesROSin the ...

Combining both genomic analysis and highEresolution imaging on a cellEbyEcell basis typically relies on customized technology which often requires significant expertise and capital costCell MicrosystemsInchas partnered with Peter SimsPhD of Columbia University to commercialize a novel workflow for integrated imaging and sample preparation for single cell transcriptomic analysisDrSims workflowSingl ...

Tumor Irradiation during cancer treatment induces clonogenic death that can be best assessed by colony forming assaysThese colony forming assays are laborious and never utilized in high throughput screeningHTSformatsWe propose to develop anintegrated platform for HTS clonogenic survival assayfor cancer drug screening as well as radiation effect modulation screeningNamedI PARTSIntegrated platform f ...

Under the Small Business Innovation Research ProgramSBIRPhase I programTopicthe Contractor will develop an integrated device and system for drug detection and deactivation to deter controlled substance theft in hospitals and other healthcare delivery settings

PROJECT SUMMARY Non steroidal anti inflammatory drugsNSAIDsare a first line pharmacologic pain therapy for chronic musculoskeletal painand rheumatoid arthritisRAand moderate to severe osteoarthritisOAspecificallyHoweverinsufficient pain relief by NSAID monotherapy has encouraged the use of combination therapyCombinations of NSAIDs plus weak opioids are widely used although objective evidence for e ...

PROJECT SUMMARYABSTRACTSpinal cord injurySCIaffects an estimatedAmericansDamage to nerves in the spinal cord can result in a loss of voluntary control over bladder and bowel function that often produces both incontinence and retention of urine and stools in the same patientThe standard of care for urine retention is bladder catheterization to void urinewhich may produce urinary tract infectionsUTI ...

Project Summary/Abstract – The EPA maintains a Toxics Release Inventory of andgt;650 toxic chemicals that are disposed or released from andgt;20,000 industrial sites in the United States, while HHS and USDA maintain a list of over 60 select agents and toxicants that pose a severe risk to human, animal, and plant health. These compounds represent only a fraction of the known and unknown environme ...

Abstract Significance: Donor tissue shortage remains a critical problem in lung transplantation. Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds. These scaffolds, created from the donor’s tissue, become functionalized after recellularization with a patient’s own cells. However, translation of whole-lun ...