Award Data

The overall objective of this proposal is to develop an in vitro process by which cancer stem cells CSC can be isolated from primary human tumor biopsies or tissues expanded without losing critical elements of stem cell qualities and then used for preclinical and clinical applications During this fast track proposal KIYATEC will employ an integrated functional and unbiased scientific strate ...

DESCRIPTION provided by applicant Atrial fibrillation AF is the most prevalent type of cardiac arrhythmia in the developed world affecting million people in the United States alone a number that is expected to double by because of population aging Current pharmacological options are ineffective which may be in part because these drugs fail to target key pathogenic mechanisms Recen ...

DESCRIPTION provided by applicant Each year million Americans go to health care providers because of vertigo dizziness or balance problems It is the second most common complaint heard in doctorandapos s offices and will occur in of the nationandapos s population at sometime in their lives From through of US adults aged years and older million Americans had ve ...

DESCRIPTION provided by applicant Methamphetamine MA dependence is associated with long term damage to regions of the brain that control cognitive and psychiatric function One third to one half of MA dependent adults experience persistent cognitive and other psychiatric disorders up to three years or longer into remission The neuropsychiatric impairments that persist following abstinence ar ...

DESCRIPTION provided by applicant Human brain development represents a highly vulnerable time to chemical exposures because immature cells are actively undergoing differentiation into more complex cell types e g neurons astrocytes oligodendroglia to form neural circuits A major reason for this vulnerability is that neuronal differentiation requires critical time dependent changes to the ...

DESCRIPTION provided by applicant Clean water is one of the most basic societal needs in the world Few situations incite more public outcry than when a community learns that their drinking water has been tainted Two of the biggest threats to groundwater quality in the U S are contamination from either chlorinated solvents or petroleum Left unattended the size and scope of the problems asso ...

DESCRIPTION provided by applicant Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of signi ...

DESCRIPTION provided by applicant The world is rapidly heading towards a pre andapos s scenario when it comes to fighting infectious disease Antimicrobial resistance is a growing problem on a global scale greatly hampering our abilities to quell worldwide epidemics such as tuberculosis and malaria as well as the simple staphylococcus infection The proposed project is significant and has ...

DESCRIPTION provided by applicant There is an inadequate supply of donated human soft tissues for a variety of surgical applications Use of the patientandapos s own tissues is often effective but is associated with morbidity or not available due to prior use or inadequate due to pre existing disease We have been developing new cryopreservation methods that avoid ice formation which damages t ...

DESCRIPTION provided by applicant Glioblastoma GBM is an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomide TMZ Efforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brain In contrast sensitizing GBM to TMZ is an appealin ...