Award Data

Project Summary This SBIR Urgent Competitive Revision will develop the first affinity membrane to purify therapeutic mRNA with high selectivity and throughput. mRNA-based pharmaceuticals have potential to address a wide variety of pathologies. mRNA-based vaccines can increase safety and dramatically shorten development timelines in pandemic scenarios. A number of mRNA-based COVID-19 vaccines are u ...

Development of a Novel Bio Adhesive Mesh System for Abdominal Hernia Repair Project Summary Abstract This project proposes the development of a novel mesh adhesive system for abdominal hernia repair utilizing surface modification of polymer surgical mesh to allow for improved tissue fixation with a poloxamine hydrogel adhesiveMore thanmillion Americans undergo hernia repair with surgical mesh each ...

ABSTRACT Technological advancements in colonoscopic and polypectomy procedures have drastically reduced both the incidence and overall mortality due to colorectal cancerCRCHowevereven with the availability of multiple screening toolsonlyof CRC are diagnosed at early stagein part due to lack of compliance with follow up colonoscopy procedurelimited access to colonoscopyThese factors contribute to i ...

Diagnosing glomerular diseases accurately and in timely fashion is key to developing a successful treatment plan and thereby prevent their progression to ESRDend stage renal diseaseHowevertheir successful diagnosis remains challenging due to the complex diagnostic procedures used including invasive renal biopsiesThusthere is a compelling need to develop simplified procedures to detect glomerular d ...

The critical importance of solid state NMRssNMRwas recently demonstrated byafter nearly two decades of intense effortsyielding the first atomic resolution structures of the Aand Aamyloid fibrils that play acrucial role in Alzheimer s DiseaseADKey to that advance is a technique denoted as dynamic nuclearpolarizationDNPwith magic angle spinningMASFor technical reasonsdiscussed belowthese experiments ...

Project Summary This SBIR Phase I project will address the need for a product that can dramatically increase the recovery and purification speed for viral vectors used in gene therapySeven thousand rare diseases that have few or no treatment options are affectingof the US populationAlthough gene therapies are promising for the treatment of many rare diseasesmost are at an early stage of developmen ...

PROJECT SUMMARYThe threat of a nuclear attack or disaster resulting in mass casualties is of increasing concernRadiation injury frequently occurs in combination with thermal burnsCombined radiation and thermal burn injuryCRBIresults in impaired wound healingexacerbated symptomsand synergistic increases in mortalityCountermeasures that synergistically address the complex pathophysiology of CRBI at ...

ABSTRACT This proposal focuses on translation of ice free cryopreservation by vitrification employing a novel approach of volumetric heating by nanowarming using Fe nanoparticles in an alternating electromagneticeldVitrificationsub zero storage below the glass transition temperature in aglassyrather than a crystalline frozen phaseis a form of cryopreservation that avoids ice formationVitri cation ...

PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

PROJECT SUMMARYHereditary cancer risk assessment in low resource community cancer settings is a signi cant unmet clinical needUnfortunatelymost community cancer clinics do not have adequate access to genetics expertise and patients are not systematically assessed for hereditary riskNew cost e ective and practical approaches are needed to assess and identify patients at risk for hereditary cancer c ...