Award Data

ABSTRACT Human prion diseases are infectious and invariably fatal neurodegenerative diseases including sporadic Creutzfeldt Jakob disease sCJD the most common form and variant CJD vCJD which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy Currently there is not sensitive objective and non invasive biochemical diagnosis for these diseases and even ...

DESCRIPTIONprovided by applicantProteolytic Imaging of Remodeling Myocardium Abstract Heart attacksi emyocardial infarction or MIoccur in more thanmillion patients annuallyAdvances in interventional and pharmacological therapies have dramatically improved survival following the initial MIand patients are often surviving acute MI with more extensive myocardial injuryConsequentlythe number of patien ...

DESCRIPTION provided by applicant Cancers of the oral cavity and pharynx are among the most serious cancers with approximately incidents globally In the US the year survival rate is approximately among the lowest for all forms of cancer Yet when diagnosed in the early stages with confinement to the primary site the rate increases dramatically to about Further cancers of the oral cavity are among t ...

Under this Small Business Innovation Research SBIR Phase II project Research Topic for "XDA eXperimental Design Assistant" the Contractor shall complete development of a platform to assist addiction and other life science investigators in designing in vivo animal experiments

DESCRIPTION provided by applicant Stroke the leading cause of disability cognitive impairment and death in the US imposes significant financial and personal burden The residual effects of stroke affect many aspects of life not addressed by traditional rehabilitation treatments In particular persons with mild stroke typically defined as a stroke with no or sligh motor impairment and a high ...

DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with highest mortality rate of all stroke subtypes and long term disability Since there are no available FDA approved therapies for ICH it is of enormous importance to establish effective treatment for this medical condition Following ICH the deposited blood is damaging initially via compression ...

DESCRIPTION provided by applicant Recent scientific investigations have shown that many chemicals used in plastics pharmaceuticals pesticides cosmetics food additives etc are endocrine disrupting chemicals EDCs EDCs interfere in various ways with hormones such as estrogens and androgens and can have significant adverse effects on many behavioral and physiological processes ED effec ...

Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral infection and pathogenes ...

DESCRIPTION provided by applicant Nucleic acids are avenues for drug design both as therapeutics and as targets Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds Targeting specific RNA such as rRNA which are involved in proliferation and survival of bacteria is a promising approach We are developing fast and low cost methods to screen s ...

DESCRIPTION provided by applicant This Small Business Innovation Research SBIR Phase I project aims to develop a microfluidic based nitric oxide NO sensor as an early sepsis risk assessment device Sepsis causes significant strain on the U S healthcare system consuming over $ billion annually due to extended hospital stays and significant morbidity and mortality Rapid diagnosis and in ...