Award Data

This Phase I project develops and evaluates a mobile application for teaching elementary and middle school aged children with intellectual and developmental disabilities toilet training skills. A team of educational experts, technology experts, and parent of a child with autism collaborate on the project to ensure the mobile application has the greatest benefit. Specific goals include: (1) develop ...

Employment is essential for helping individuals with intellectual disabilities achieve independence, financial security, and self-sufficiency to be active members in the community as well as foster a higher quality of life more generally. However, only 25% of individuals with intellectual disabilities are employed two years after high school. Utilizing 3C’s proprietary dynamic e-learning platfor ...

DESCRIPTION (provided by applicant): Patients with chronic anemia (i.e., anemia of inflammation) frequently find that iron repletion cannot be achieved with oral iron fortificants. The current standard of care for these patients is infusion of intravenous(IV) iron-carbohydrate complexes. These complexes must be processed in the liver to render iron available for erythropoiesis. Therefore, after a ...

DESCRIPTION (provided by applicant): Information from next generation sequencing is widely used in translational studies and promises to be a cornerstone of personalized medicine where therapeutic courses are linked to an individual's genetic makeup. Extraction of DNA from gels following electrophoresis to obtain size-selected DNA fragments is a labor intensive part of library preparation ...

DESCRIPTION (provided by applicant): Project summary: The project summary with the exception of the first five lines contains proprietary/privileged information that Dr. Ramloll requests not be released to persons outside the Government, unless for purposes of review and evaluation. (Number of lines in paragraph below = 30) Given the growing body of research results reporting the benefits of usi ...

DESCRIPTION (provided by applicant): Rhabdomyosarcoma (RMS) is a childhood malignant tumor and is thought to arise due to the arrest of skeletal muscle differentiation (myogenesis) program. It accounts for 3.5% of all malignancies in children. Despite multimodality therapeutic treatment approaches, the outlook for patients with metastatic subtype, alveolar rhabdomyosarcoma (ARMS), remains unchange ...

DESCRIPTION (provided by applicant): Although nanomaterials have tremendous potential to improve human health, it has remained surprisingly elusive to leverage their properties to produce real clinical impact. One of the most promising applications of nanoparticles is in sensors for detection of analytes. For sensors that need to be performed at the point of care (POC), one large barrier to unlock ...

DESCRIPTION (provided by applicant): As a normal consequence of aging, most men experience some form of erectile dysfunction (ED), which, in severe cases, causes impotence (the inability to sustain an erection sufficient to engage and complete vaginal intercourse). Conservative estimates place the incidence of all forms of ED in the general population at 30 million cases; the percentage in the ag ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

DESCRIPTION (provided by applicant): This Phase I SBIR application is submitted in response to the call by DHHS for new tests for qualitative measurement of HCV RNA for diagnosis of chronic HCV infection in patients. The need is for HCV RNA assays that areas reliable but less expensive and resource-demanding than current molecular assays. The new test proposed for research and development consists ...