Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

DESCRIPTION (provided by applicant): Most drugs interact with protein molecules to elicit a cellular response. Traditional drug discovery is a laborious and expensive experimental process, so computational approaches to assess protein function and to accelerate the discovery process are in high demand. Virtual drug screening and structure-based drug design represent computational approaches that c ...

In response to SBIR topic A07-023, Impact Technologies, collaborating with Allient Techsystems, Incorporated (ATK), proposes to develop and demonstrate a modular embedded vibration management platform for the collection, signal processing, real-time analysis, and reduction of vibration data. The proposed asset-mounted sensor will be capable of long term autonomous collection and analysis of vibrat ...

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DESCRIPTION (provided by applicant): Patient-centered care recognizes patients' desires, opinions, and preferences as equal in importance to those of healthcare professionals, and emphasizes the need to educate and empower patients to play an active role in their care. The achievement of patient-centered care is associated with increased patient and provider satisfaction, improved health outc ...

DESCRIPTION (provided by applicant): Seasonal influenza constitutes a significant healthcare problem in the U.S., with an estimated 17 to 50 million persons affected yearly. Influenza was responsible for an average of 36,000 deaths annually throughout the decade 1990-1999. Elderly patients are at particular risk, accounting for 80-90% of influenza related deaths. In the US, the economic cost of th ...

The goal of this project is to design multi-octave beamformer systems capable of compensating for on-aircraft effects on element patterns. This requires addressing (1) mutual coupling in the array, and (2) near-field scattering from the airborne platform. Amplitude and phase control at each element of the array could be employed to compensate for the on-aircraft effects but the power loss caused ...

A higher performing arresting cable that is lighter in weight by virtue of an optimized combination of advanced core materials, weave patterns, lubrication, wire strand alloys with higher strength and damage resistance, and innovative termination design is proposed. The concept will be proven through a rigorous and extensive 7-step comparative test and analysis program. The proposed configuration ...

Using a solvent free electrode manufacturing process, several different electrochemical couples will be tested using the C123 sized cell as the test bed. Both rechargeable and primary chemistries will be processed using the solventless electrode process that was successfully developed under a previous proof of concept BATTNET program effort. This effort will demonstrate the application of the pr ...