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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: NIA

    Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A biomarker of aging as a predictor of kidney transplant function

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: NIA

    ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Abuse Deterrent Transdermal Drug Delivery System for Fentanyl

    SBC: BIONEX PHARMACEUTICALS LLC            Topic: NIDA

    Pain is the single greatest cause of disability and its management remains one of medicine s foremost challenges Potent opiates can effectively reduce the severity of pain thereby diminishing patient suffering Unfortunately chronic use of these drugs can be harmful to patients whether by inadvertent overdosing unintentional addiction or abuse resulting from dependency on the euphoric effec ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    Project Summary Nucleosomes are the fundamental and repeating units of chromatin consisting of DNA wrapped around a histone octamer Alterations in chromatin structure and function dramatically impact downstream gene expression and cellular physiology This epigenetic regulation is controlled by two major modifications histone post translational modifications PTMs such as histone methylation ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A Combination Endovascular Device Therapeutic Hypothermia with Stentriever Devices

    SBC: Tom L Merrill            Topic: 106

    Project Summary Stroke is the th leading cause of death and number one cause of adult disability in the United States The primary goal of ischemic stroke treatment is quickly restoring blood perfusion However studies have shown that this return of blood flow while necessary can also cause damage to local tissue Hypothermia has been shown to decrease this reperfusion injury The overall go ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Data-driven Approach to Improve Nursing Workflow and Patient-centered Care

    SBC: Transcendent International, LLC            Topic: NIMHD

    DESCRIPTION (provided by applicant): Patient-centered care recognizes patients' desires, opinions, and preferences as equal in importance to those of healthcare professionals, and emphasizes the need to educate and empower patients to play an active role in their care. The achievement of patient-centered care is associated with increased patient and provider satisfaction, improved health outc ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Advanced Cannula Development for Coronary Sinus Access

    SBC: STRATEGIC PACING SYSTEMS LLC            Topic: NHLBI

    DESCRIPTION provided by applicant This Phase STTR will develop novel techniques for coronary sinus access The coronary sinus provides unique anatomic and physiologic proximity to all four cardiac chambers and the coronary circulation For example the coronary sinus is used for left ventricular lead insertion for biventricular pacing or cardiac resynchronization Mor than such implan ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Advanced laser system for photoacoustic endomicroscopy

    SBC: LIGHT AGE, INC.            Topic: 102

    DESCRIPTION provided by applicant The emerging light based imaging technique of acoustic resolution photoacoustic endomicroscopy AR PAEM enables visualization of subsurface tissues with microscopic resolution at depths of many millimeters AR PAEM images provide crucial information regarding microvasculature morphology and tissue physiology blood oxygenation For cancers originating in ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Affinity Capture Peptides for Clinical Mass Spectrometric Assays in Plasma

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): We will develop the first assay for multiplexed combinations of all 14 Bone Morphogenetic Proteins. Immunoassays are the gold standard for measuring proteins in clinical samples. However these antibody- based tests neither quantitate protein analyte variants, nor multiplex across large numbers of superfamily members. In addition, the availability of polyclona ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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