Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

Pain is the single greatest cause of disability and its management remains one of medicine s foremost challenges Potent opiates can effectively reduce the severity of pain thereby diminishing patient suffering Unfortunately chronic use of these drugs can be harmful to patients whether by inadvertent overdosing unintentional addiction or abuse resulting from dependency on the euphoric effec ...

Project Summary Nucleosomes are the fundamental and repeating units of chromatin consisting of DNA wrapped around a histone octamer Alterations in chromatin structure and function dramatically impact downstream gene expression and cellular physiology This epigenetic regulation is controlled by two major modifications histone post translational modifications PTMs such as histone methylation ...

Project Summary Stroke is the th leading cause of death and number one cause of adult disability in the United States The primary goal of ischemic stroke treatment is quickly restoring blood perfusion However studies have shown that this return of blood flow while necessary can also cause damage to local tissue Hypothermia has been shown to decrease this reperfusion injury The overall go ...

DESCRIPTION (provided by applicant): Patient-centered care recognizes patients' desires, opinions, and preferences as equal in importance to those of healthcare professionals, and emphasizes the need to educate and empower patients to play an active role in their care. The achievement of patient-centered care is associated with increased patient and provider satisfaction, improved health outc ...

DESCRIPTION provided by applicant This Phase STTR will develop novel techniques for coronary sinus access The coronary sinus provides unique anatomic and physiologic proximity to all four cardiac chambers and the coronary circulation For example the coronary sinus is used for left ventricular lead insertion for biventricular pacing or cardiac resynchronization Mor than such implan ...

DESCRIPTION provided by applicant The emerging light based imaging technique of acoustic resolution photoacoustic endomicroscopy AR PAEM enables visualization of subsurface tissues with microscopic resolution at depths of many millimeters AR PAEM images provide crucial information regarding microvasculature morphology and tissue physiology blood oxygenation For cancers originating in ...

DESCRIPTION (provided by applicant): We will develop the first assay for multiplexed combinations of all 14 Bone Morphogenetic Proteins. Immunoassays are the gold standard for measuring proteins in clinical samples. However these antibody- based tests neither quantitate protein analyte variants, nor multiplex across large numbers of superfamily members. In addition, the availability of polyclona ...