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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Intelligent Biometrics to Optimize Prolonged Exposure Treatment for PTSD (IB-PE)

    SBC: Zeriscope, Inc.            Topic: 104

    PROJECT SUMMARY/ABSTRACT Posttraumatic Stress Disorder (PTSD) is a debilitating disease affecting millions of American military veterans and civilians. Prolonged Exposure (PE) therapy is evidence-based and effective but limited by high dropout rates and incomplete resolution of symptoms in approximately one-third of patients. A crucial component of PE, as well as interventions for anxiety disorder ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Custom-Fit Personal Sound Amplification Smartphone Application

    SBC: ASCENDING HEARING TECHNOLOGIES, LLC            Topic: NIDCD

    PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A novel asthma drug candidate targeting the GABAergic system in lung inflammation

    SBC: PANTHERICS INCORPORATED            Topic: NHLBI

    The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Evaluation of a Novel Connexin-Based Peptide in the Treatment of Combined Ionizing Radiation and Thermal Burn Injury

    SBC: FirstString Research, Inc            Topic: NIAID

    PROJECT SUMMARYThe threat of a nuclear attack or disaster resulting in mass casualties is of increasing concernRadiation injury frequently occurs in combination with thermal burnsCombined radiation and thermal burn injuryCRBIresults in impaired wound healingexacerbated symptomsand synergistic increases in mortalityCountermeasures that synergistically address the complex pathophysiology of CRBI at ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Online Thermoacoustic Range Verification Overlaying Treatment Spot onto Ultrasound Images for Synchrocyclotron Proton Therapy Systems

    SBC: Acoustic Range Estimates, LLC            Topic: 102

    Particle therapy is a technique for treating solid tumors that is potentially more precise than x ray radiation therapyCharged particles enter the patient at relativistic speedsdepositing increasingly more dose as they come to rest inside the patientX ray photon beams deliver an exponentially decaying dose along the beam pathdosing healthy tissue before and after the tumorWhen patient alignment is ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Discovery of cGAS Inhibitors for Interferon-Driven Autoimmune Diseases

    SBC: Bellbrook Labs, LLC            Topic: NIAID

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferonIFNresponse via activation of the STINGstimulator of interferon genesreceptorThe sensor for cytoplasmic nucleic acids was recently discovered to be cyclic GMP AMP synthasean enzyme that produces a unique cyclic dinucleotide second messengercGAMPthat serves as an agonist for the STI ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Aminoglycosides with reduced ototoxicity via miRNA targeting

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well-known antibiotics in clinical use for over 70 years, but one of the major limitations in their use is their ototoxicity. We are developing fast and low cost methods to develop aminoglycosides with anti- ribosomal activities and reduced toxicity. In this project, we will identify novel aminoglycoside antibacterials, that show reduced o ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Web Based Therapist Training on Complicated Grief Therapy

    SBC: KOBAK, KENNETH A            Topic: 104

    Complicated Grief (CG) is a prevalent and debilitating disorder associated with significant distress and impairment. It differs from major depression in its treatment and symptomatology. CG is listed in DSM5 as a subtype of Trauma and Greif Disorder. The World Health Organization will include CG as a stand-alone disorder in ICD11, and it is expected that the DSM 5.1 subcommittee will follow suit. ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. An Efficient System for 30-K MAS-NMR-DNP for Macromolecule Structure Determinations

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    The critical importance of solid state NMRssNMRwas recently demonstrated byafter nearly two decades of intense effortsyielding the first atomic resolution structures of the Aand Aamyloid fibrils that play acrucial role in Alzheimer s DiseaseADKey to that advance is a technique denoted as dynamic nuclearpolarizationDNPwith magic angle spinningMASFor technical reasonsdiscussed belowthese experiments ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. An in vitro diagnostic assay for the early and accurate detection of platelet-activating antibodies associated with Heparin-induced Thrombocytopenia

    SBC: Retham Technologies LLC            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT This SBIR proposal is aimed at demonstrating feasibility of developing a technically simple and highly accurate in vitro diagnosticIVDassay for Heparin induced thrombocytopeniaHITa serious complication of heparin treatmentThe proposed assay is based on recent findings that Platelet FactorPFtreated platelets can be used for the sensitive and specific detection of clinically ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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