Award Data

DESCRIPTION (provided by applicant): Our long-term research goal is to develop an ophthalmic, nanofiber-based, biodegradable device that will provide extended release of therapeutic agents to the posterior segment of the eye via transscleral and intravitr eal approaches. This platform device will address the major technical problem in the treatment of posterior eye diseases (diabetic retinopathy, ...

Project Summary The objective of this Phase I SBIR proposal is to demonstrate the feasibility of a device designed to connect two small vessels together simply and easily and that would replace the hand suturing technique currently used to connect vessels in microsurgery and macrovascular end to end vascular repair surgeries This completely biodegradable vascular coupling device VCD being devel ...

Project Summary The objective of Microsurgical InnovationsMSIin this proposal is to develop a biodegradable vascular coupling deviceVCDwhich would replace the hand suturing technique currently used to connect arteries and veins in microvascular and macrovascular end to end vascular repair surgeriesOur device works for both arteries and veins and can rapidly connect the two vessel ends together in ...

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Glycosaminoglycans (GAGs) are polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrix. More recently, changes in the content, size, and composition of GAGs have been found to play biological roles in disease processes as well. For example, chondroitin sulfate (CS) is the most abunda ...

Use of a new noninvasive test for the accurate early detection of preeclampsia is proposed as a tool to screen women during early stages of pregnancy. Preeclampsia affects 10% of the 4 million pregnancies in the U.S. each year and is the leading cause of maternal and neonatal medical complications and death. There is currently no means of detecting preeclampsia prior to onset of clinical symptoms ...

DESCRIPTION (provided by applicant): Accurate measurement of core body temperature during surgery as well as in critical care is imperative to a positive outcome and ongoing quality of life for patients. Core temperature management of patients during extended anesthesia such as cardio-pulmonary bypass (CPB) surgery is equally important, yet there is no accurate core body measurement device availab ...

DESCRIPTION provided by applicant There is a growing need for accurate and continuous non invasive monitoring of brain temperature in hospitals and clinics throughout the world The need for physicians and anesthesiologists to know the brain as well as the core body temperature of a patient is well established Temperature management of patients under anesthesia during cardio pulmonary bypass s ...

FINDING AND DISABLING A BALLISTIC MISSILE IN FLIGHT REQUIRES THE COORDINATION OF MANY, TIGHTLY INTEGRATED FUNCTIONAL ELEMENTS. TRADITIONALLY, SUCH SYSTEMS ARE DESIGNED AS INDEPENDENT COMPONENTS WITH CLEARLY DEFINED INTERFACES, SO THAT THERE IS A CLEAR SEPARATION BETWEEN MODULE AND CLIENT. SUCH SYSTEMS PASS DATA TO EACH OTHER BUT DO NOT OTHERWISE COLLABORATE IN THE OVERALL SYSTEM GOALS. THEY ALSO A ...

Supercapacitors have attracted considerable recent attentions due to their high-power density, and long cycle life. Unfortunately, the energy density of supercapacitors is too low to meet these applications requiring an energy supply for longer periods (hours or days). Storagenergy Technologies Inc. proposes to develop a superior all solid-state battery (ASSB) fabricated by additive manufacturing ...