Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A New Technique for Diabetic Foot Ulcers

    SBC: Noveratech LLC            Topic: 200

    ABSTRACT Diabetes is the leading cause of nontraumatic lower extremity amputations in the United States Diabetic foot ulcers DFUs are responsible for more hospitalizations than any other diabetic complications Currently even the best available treatments achieve only a healing rate for these wounds and this healing is often only temporary with a chance of recurring Our company has ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. A mechanism based computational tool to optimize pulmonary drug delivery

    SBC: CFD Research Corporation            Topic: 300

    DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Chikungunya Recombinant Subunit Vaccine

    SBC: Hawaii Biotech, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Chikungunya virus CHIKV is an alphavirus classified as a category C priority pathogen that causes fever rash and arthralgia in humans In the past decade CHIKV outbreaks have spread beyond the endemic regions of Africa and Asia first to the islands in the Indian Ocean and most recently to the Americas The World Health Organization has reported that as ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Tumor Proliferation PET Tracer FLT using a Low Cost Single Dose Automatic Production and Quality Control Biomarker Generator System

    SBC: ABT Molecular Imaging            Topic: 102

    DESCRIPTION provided by applicant Worldwide a person dies from cancer every seconds Positron emission tomography PET is an effective tool that is critical in diagnosing cancer and monitoring treatment efficacy PET imaging relies on use of short lived radioisotopes Commercial distribution of the most commonly used radio tracer F FDG has resulted in patient population coverage in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  6. Glycosaminoglycan Interacting Small Molecule GISMO as Parkinson s Therapeutic

    SBC: Gismo Therapeutics Inc.            Topic: 106

    Glycosaminoglycan Interacting Small Molecule GISMO As Parkinsonandapos s Therapeutics ABSTRACT Current approved drugs for Parkinsonandapos s Disease PD treat the symptoms of the disease but do not stop disease progression This project is focused on developing a new disease modifying PD therapeutic with a novel mode of action that is expected to block disease progression Recent data indicate ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Mouth barrier rinse of sustained release poly curcumin to treat oral mucositis

    SBC: Bluegrass Advanced Materials, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant Oral mucositis OM is one of the most common side effects of most anti cancer therapies affecting nearly of head and neck cancer patients of the million new cancer cases worldwide annually OM manifests by deep and extremely painful mouth ulcers that can force patients to halt life saving anti cancer treatments and experience increased emerge ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Mutant transgenic plant cells as a novel source of drugs

    SBC: NAPROGENIX, INC.            Topic: 150

    Abstract of administrative supplement The original objective was to use a novel plant biotechnologytarget directed evolutionto produce novel inhibitors of the human dopamine transporterDATas leads for medications for alcohol use disorderThis approach evolves plant biosynthesis toward a specific target by a combination of mutagenesis and selectionLobelia cardinalis was used as the plant species bec ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes

    SBC: IXPRESSGENES, INC.            Topic: CBD152004

    Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  10. Protective Mask Sizing App

    SBC: CFD Research Corporation            Topic: CBD161005

    Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
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