Award Data

Pain is the single greatest cause of disability and its management remains one of medicine s foremost challenges Potent opiates can effectively reduce the severity of pain thereby diminishing patient suffering Unfortunately chronic use of these drugs can be harmful to patients whether by inadvertent overdosing unintentional addiction or abuse resulting from dependency on the euphoric effec ...

The IAN Team, unique in its exceptional experience in EMP protection, materials science, microgrid development and management of industrial facilities needed by DCI, proposes to develop innovative strategies and methodologies for DCI island-mode operations in the event of power grid disruption or failure due to an EM threat.These island mode operations will be supported by advanced EMP shielding m ...

Project Summary This proposal addresses the NICHD focus of specific interest for the prevention of child abuse and neglect in at risk populations Child abuse and neglect often confers short and long term impairment of the physical emotional and cognitive development of children The proposed project builds on promising data from previous randomized control trials based on application of a scr ...

Project Summary Stroke is the th leading cause of death and number one cause of adult disability in the United States The primary goal of ischemic stroke treatment is quickly restoring blood perfusion However studies have shown that this return of blood flow while necessary can also cause damage to local tissue Hypothermia has been shown to decrease this reperfusion injury The overall go ...

DESCRIPTION provided by applicant In this Phase I SBIR project Technology Assessment andamp Transfer Inc TAandamp T and their collaborator propose development of ceramic additive manufacturing aka D printing for production of high performance ceramic dental restorations in the dental laboratory environment A ceramic additive manufacturing approach to fabricating dental restorations ha ...

DESCRIPTION provided by applicant This Phase STTR will develop novel techniques for coronary sinus access The coronary sinus provides unique anatomic and physiologic proximity to all four cardiac chambers and the coronary circulation For example the coronary sinus is used for left ventricular lead insertion for biventricular pacing or cardiac resynchronization Mor than such implan ...

DESCRIPTION provided by applicant The emerging light based imaging technique of acoustic resolution photoacoustic endomicroscopy AR PAEM enables visualization of subsurface tissues with microscopic resolution at depths of many millimeters AR PAEM images provide crucial information regarding microvasculature morphology and tissue physiology blood oxygenation For cancers originating in ...

DESCRIPTIONprovided by applicantThe world needs a highly effective malaria vaccineSanaria rPfSPZ Vaccinecomposed of asepticpurifiedcryopreserved radiation attenuated PfSPZprotectedof volunteers in an NIH clinical trialThe vaccine has been administered by direct venous inoculationDVItosubjects in MaliTanzaniaEquatorial GuineaEGand USASafetytolerabilityhigh grade protectionheterologous protection af ...

DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

Abstract The ultimate goal of the proposed research is to develop a multiplex assay for early detection of Cutaneous T Cell Lymphoma CTCL in human serum or plasma Mycosis fungoides MF is a slowly progressive form of CTCL that initially manifests by non specific cutaneous eczematous patches and plaques similar to atopic dermatitis eczema psoriasis and other benign dermatoses The early d ...