Award Data

ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

THE TECHNICAL OBJECTIVES OF THIS PROPOSAL ARE ORIENTED TOWARD THE DEVELOPMENT OF SOIL SURFACTANT FLUSHING AND WASHING AS A LOW-COST, LOW-IMPACT, LOW-RISK, EFFECTIVE TECHNIQUE FOR THE REMOVAL AND ULTIMATE DESTRUCTION OF THE ORGANIC CONTAMINANTS IN SOIL. THESE OBJECTIVES ARE: DEMONSTRATION OF THE EFFECTIVENESS OF AN IONIC SURFACTANT SOLUTION AT CONCENTRATIONS ABOVE THE CRITICAL MICELLE CONCENTRATION ...

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Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

THIS RESEARCH STUDY DEVELOPS AN INTERACTIVE, MICROCOMPUTER-BASED, PICTURE ICON LAYOUT AND AUTHORING SYSTEM FOR EDUCATORS, COMMUNICATIONS SPECIALISTS, AND EDUCATIONAL TECHNOLOGISTS WHO ADAPT OR FABRICATE COMMUNICATIONS AIDS AND SYSTEMS FOR NON-VOCAL OR SPEECH-IMPAIRED CHILDREN OR ADULTS. A PROTOTYPE PICTURE ICON LAYOUT SOFTWARE (PILS) SYSTEM WILL BE DESIGNED FOR THE UNICORN II EXPANDED KEYBOARD (UN ...

Abstract The disorders collectively known as inflammatory bowel disease IBD including Crohn s disease CD and ulcerative colitis UC affect up to one and a half million Americans Both result from uncontrolled chronic inflammatory activity in the GI tract Most therapeutic agents act by down regulating inflammation are not curative and suffer from significant side effects Forty to of pat ...

DESCRIPTION provided by applicant Mutations in the ras family of genes were first identified in human cancer over years ago Such mutations result in the constitutive activation of one or more of three major Ras protein isoforms including H Ras N Ras or K Ras that mediate important signaling pathways leading to uncontrolled cell growth and tumor development Activating ras gene mutations ...

DESCRIPTION provided by applicant More than U S patients have end stage renal disease and over utilize hemodialysis as their renal replacement modality of choice The Achilles Heel in the care of dialysis patients is the development of a functioning and durable vascular access preferably an arteriovenous fistula The annual cost of treating vascular access dysfunction totals over ...

Abstract of administrative supplement The original objective was to use a novel plant biotechnologytarget directed evolutionto produce novel inhibitors of the human dopamine transporterDATas leads for medications for alcohol use disorderThis approach evolves plant biosynthesis toward a specific target by a combination of mutagenesis and selectionLobelia cardinalis was used as the plant species bec ...