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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. IED neutralization from an airborne platform

    SBC: Imsar LLC            Topic: DTRA182001

    In cooperation with the Joint Improvised-threat Defeat Organization (JIDO) and the U.S. Army, IMSAR LLC demonstrated its radar systems' ability to successfully detect IED emplacements from the RQ-7B Shadow Unmanned Aerial System (UAS). As part of the Armys ShadowSAR program, IMSAR operated and maintained these Synthetic Aperture Radar (SAR) sensors for 4years in support of Operation Enduring Freed ...

    SBIR Phase I 2019 Department of DefenseDefense Threat Reduction Agency
  2. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Targeted Intraceptors for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: NEI

    Project Summary Age related Macular DegenerationAMDis the leading cause of blindness in USIt affects overof the people by the ageAn estimatedmillion people are afflicted with AMD worldwideNeovascular orwetAMDwhich affectsof AMD patientsis a rapid form of the disease and progresses to blindness if left untreatedHistopathologicallythe disease involves lesions in the Bruchandapos s membrane and or re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. SBIR Phase II: Protein A Membrane Columns for Rapid Protein Purification

    SBC: Purilogics, LLC            Topic: 400

    Project Summary This SBIR Phase II project will address the need for capture step chromatography products that dramatically increase the isolation and purification speed for therapeutic biologicsparticularly monoclonal antibody drugsNumerous campaigns are under way to develop new biologics for treating chronic conditionsand there is increasing demand for affordable and fastsmall batch production r ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Accessible And Robust Tools for Glycosaminoglycan Profiling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: 300

    GlycosaminoglycansGAGsare polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrixMore recentlychanges in the contentsizeand composition of GAGs have been found to play biological roles in disease processes as wellFor examplechondroitin sulfateCSis the most abundant GAGhoweveronly th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Novel Bio-Adhesive Mesh System for Abdominal Hernia Repair

    SBC: CIRCA BIOSCIENCE, LLC            Topic: 300

    Development of a Novel Bio Adhesive Mesh System for Abdominal Hernia Repair Project Summary Abstract This project proposes the development of a novel mesh adhesive system for abdominal hernia repair utilizing surface modification of polymer surgical mesh to allow for improved tissue fixation with a poloxamine hydrogel adhesiveMore thanmillion Americans undergo hernia repair with surgical mesh each ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Natural Products-Based High Throughput Screen: Identification of Correctors of Cystic Fibrosis Misfolding Mutants

    SBC: Synthetic Biodesign, LLC            Topic: NCCIH

    Natural products or their derivatives have accounted for most of our current drugsdemonstrating their unique status asprivilegedmolecules that are well adapted for therapeutic useHowevernatural products have previously been unsuitable for modernhigh throughputHTdrug discovery screening approachesand as suchwere long ago abandoned in drug discovery programs of large pharmaThe substitute has been hi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Identifying the precursor to oxytocin-induced uterine tachysystole by monitoring with uterine EMG

    SBC: PreTel, Inc.            Topic: NICHD

    Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Developing and validating a podocyte cell-based diagnostic assay for identifying recurrent focal and segmental glomerulosclerosis patients

    SBC: InDepth Pharmaceuticals, LLC            Topic: 400

    Diagnosing glomerular diseases accurately and in timely fashion is key to developing a successful treatment plan and thereby prevent their progression to ESRDend stage renal diseaseHowevertheir successful diagnosis remains challenging due to the complex diagnostic procedures used including invasive renal biopsiesThusthere is a compelling need to develop simplified procedures to detect glomerular d ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos s diversitAbplatform by continuing advanced development of Transchromosomic goatsTcGsThis will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos s human artificial chromosomeHACwhich encodes the entire ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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