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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Image-Guided Transurethral HIFU for Genitourinary Therapy

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: 400

    DESCRIPTION provided by applicant Stress urinary incontinence SUI in women is an increase of pelvic floor compliance which results in decrease of urethral pressure typically through childbirth and presents as urine leakage during exertion SUI has significant impact on womenandapos s health including an association with increased levels of depression Curative options are limited to the in ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A Force-controlled Probe Based Platform for Single-Cell Biomolecular Delivery

    SBC: INFINITESIMAL, LLC            Topic: 100

    DESCRIPTION provided by applicant This proposed Phase II project will lead to a commercial product capable of transfecting individual target cells This new biotool uses a patented microfabricated chip called a nanofountain probe NFP to deliver molecules into live individual target cells by single cell electroporation which induces temporary nanopores in the cell membrane via the applicat ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Quantitative Optical Assessment of Middle Ear Disease

    SBC: PhotoniCare, Inc.            Topic: NIDCD

    DESCRIPTION provided by applicant PhotoniCare Inc is a medical device company developing a handheld biophotonics imaging system suitable for use by otolaryngologists ear nose and throat specialists ENT and primary care physicians PCP to enable real time D assessment of sub surface tissue structure in the middle ear Significance ENTs and PCPs have limited tools with which to diagn ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. High-yield production of GDP-fucose for fucosylation of molecules

    SBC: ZUCHEM INC.            Topic: 300

    DESCRIPTION provided by applicant Fucosylation plays an important role in many cellular processes Fucosylated oligosaccharides in the cell are involved in many biochemical recognition processes microbial infections toxin entry and cancer cell metastasis These properties make fucosylated molecules valuable for pharmaceutical and drug discovery needs but current production methods are very ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. HLS13-13 Albumin nanoparticle based technology to treat ARDS

    SBC: CELL BIOLOGICS INC            Topic: NHLBI

    DESCRIPTION provided by applicant Severe infections various types of trauma and other etiologic factors can cause ALI that rapidly morphs into ARDS The incidence of ALI ARDS is around in adults in US alone Despite medical advances and better management through ventilation intervention the mortality is still unacceptably high at This problem is likely to escalate given the a ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Nezavist a Novel Molecule for Treatment of Alcohol Use Disorder

    SBC: LOHOCLA RESEARCH CORPORATION            Topic: 150

    DESCRIPTION provided by applicant Alcohol Use Disorder affects of the U S population ages and older and costs society over $ billion per year in direct medical costs accidents and lost productivity Current pharmacotherapy is only modestly effective and has to be used in conjunction with psychosocial treatment Primary care physicians are ill equipped to provide the currently neces ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Human induced pluripotent stem cell-derived beta-cells for drug and toxicity testing

    SBC: Regenerative Medical Solutions Inc            Topic: 200

    DESCRIPTION provided by applicant Diabetes represents a global health crisis In the United States alone approximately million people of the population suffer from diabetes resulting in direct medical costs of $ billion National Diabetes Statistics Report New medicines that can restore cell function in these patients thereby preventing or alleviating the debilitatin ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Tumor-specific fluorescent cocktail enables image-guided cytoreductive surgery.

    SBC: On Target Laboratories, Inc.            Topic: 102

    DESCRIPTION provided by applicant Lung cancer remains the leading cause of cancer related deaths worldwide Surgical removal of the tumor is the best therapeutic option for patients with non small cell lung cancer yet up to of patients still leave the operating room with deposits of cancer left behind Advances in CAT and PET scans have provided surgeons with helpful radiographic imaging i ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Electric field-assisted membranes for organic solvent nanofiltration

    SBC: THERMOSOLV LLC            Topic: 300

    DESCRIPTION provided by applicant This multi phase SBIR project targets a significant problem within the mission of the National Institute of General Medical Sciences rapid size based separation of small Da molecules in bio manufacturing The aim here is to simplify and radically improve this currently multi stage and a resource intensive process Manufacturing of active pharmaceut ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A Proton Radiography System for Optimization of Proton Therapy

    SBC: ProtonVDA LLC            Topic: NCI

    DESCRIPTION provided by applicant Our goal is to commercialize a high performance low cost proton radiography system based on well established fast scintillator technology This system will produce images of patients in terms of proton stopping power by tracking individual protons before and after the patient and measuring the proton residual range after traversing the patient The design of o ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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